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Transdermal therapeutic systems and rate controlled drug delivery
1Alza Corporation, Palo Alto, California 94304.
Medical Progress Through Technology
|January 1, 1989
Summary
Rate-controlled transdermal therapeutic systems (TTS) offer improved systemic therapy. Examples like transdermal scopolamine and estradiol TTS demonstrate controlled drug levels and reduced side effects.
Area of Science:
- Pharmacology
- Drug Delivery Systems
- Dermatology
Background:
- Transdermal therapeutic systems (TTS) are designed for controlled drug delivery.
- System rate-control is a critical feature influencing therapeutic outcomes.
- Understanding the impact of rate-controlled TTS on systemic therapy is essential.
Purpose of the Study:
- To review the design features of rate-controlled transdermal therapeutic systems.
- To evaluate the impact of system rate-control on systemic therapy.
- To examine specific examples of rate-controlled TTS, including scopolamine and estradiol.
Main Methods:
- Literature review of transdermal therapeutic systems.
- Analysis of rate-controlled transdermal products.
- Evaluation of TTS(scopolamine) and TTS(estradiol) efficacy and safety profiles.
Main Results:
- Rate-controlled TTS ensure consistent drug plasma concentrations.
- TTS(scopolamine) use leads to reduced systemic side effects.
- Transdermal estradiol dosage forms achieve a more physiologic estradiol to estrone ratio.
Conclusions:
- System rate-control is a key design feature for effective transdermal drug delivery.
- Rate-controlled TTS, such as scopolamine and estradiol, offer significant therapeutic advantages.
- TTS technology enhances drug efficacy and patient safety through controlled systemic exposure.