Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cytomegalovirus Disease01:27

Cytomegalovirus Disease

87
Cytomegalovirus (CMV) disease is caused by human cytomegalovirus, a double-stranded DNA virus of the Herpesviridae family. While primary CMV infection is often asymptomatic in immunocompetent individuals, the virus can cause severe disease in neonates and immunocompromised patients. CMV is the most common cause of congenital viral infection in the United States, and a major pathogen in solid organ and hematopoietic stem cell transplant recipients.CMV is transmitted via bodily fluids, sexual...
87
Arboviral Encephalitis01:25

Arboviral Encephalitis

52
Arboviral encephalitis refers to brain inflammation caused by arthropod-borne viruses, particularly those transmitted through mosquito vectors. Among these, West Nile virus (WNV), a member of the Flaviviridae family, is a significant public health concern. WNV is an enveloped, positive-sense, single-stranded RNA virus. Human infection typically begins when an infected mosquito introduces the virus into the dermis during feeding. The primary transmission cycle involves birds as amplifying hosts...
52
Viral Meningitis01:18

Viral Meningitis

178
Viral meningitis is the most common form of meningitis and is often referred to as aseptic meningitis to indicate the absence of bacterial involvement. It is generally milder than bacterial meningitis, with symptoms including fever, headache, stiff neck, drowsiness, nausea, photophobia, and vomiting. Rarely, more severe manifestations or death may occur. Common causative agents include enteroviruses, particularly coxsackie A and B viruses and echoviruses, all members of the Enterovirus genus...
178
Retroviruses02:33

Retroviruses

11.8K
Retroviruses and retrotransposons both insert copies of their genetic elements into the genome of the host cell. Thus, the viral genes are passed on when the host genome is replicated or translated. A typical retroviral DNA sequence contains 3-4 genes that encode the different proteins required for its structural assembly and function as a molecular parasite. This DNA is transcribed into a single mRNA, which is very similar in structure to conventional mRNAs, i.e., it is capped at the 5’...
11.8K
Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

5.2K
Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...
5.2K
Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

4.8K
4.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

An antibiotic chatbot: Evaluation of a retrieval-augmented generation approach for providing guideline-based antimicrobial advice.

The Journal of infection·2026
Same author

Breaking the cycle: addressing the evolving dynamic of violence associated with the European drug market.

The International journal on drug policy·2026
Same author

Addressing pandemic-wide systematic errors in the SARS-CoV-2 phylogeny.

Nature methods·2026
Same author

Hidden in Plain Sight: Lessons From International Case Studies of Child Sexual Abuse in Early Childhood Education and Care Settings.

Child maltreatment·2026
Same author

The Need to Revitalise Drug Use Monitoring to Keep Pace With a More Dynamic, Digitally Enabled and Globally Connected Drug Market.

Drug and alcohol review·2025
Same author

Implication of Capillary Morphogenesis Gene 2 (CMG2) in the Disease Progression and Peritoneal Metastasis of Pancreatic Cancer.

Cancers·2024
Same journal

Use of gloves: current evidence vs. current use.

Current opinion in infectious diseases·2026
Same journal

Understanding challenges to prevention of healthcare related infections.

Current opinion in infectious diseases·2026
Same journal

Harnessing next-generation microbial diagnostics to optimize infection management in immunocompromised hosts.

Current opinion in infectious diseases·2026
Same journal

Epidemiology, treatment and outcomes of antimicrobial-resistant infections in hematopoietic stem cell transplant recipients.

Current opinion in infectious diseases·2026
Same journal

Dengue and chikungunya vaccines past, present and future: implications for travelers.

Current opinion in infectious diseases·2026
Same journal

Oropouche virus: viral evolution, epidemiological trends, and challenges for control.

Current opinion in infectious diseases·2026
See all related articles

Related Experiment Video

Updated: Apr 22, 2026

Use of In vivo Imaging to Monitor the Progression of Experimental Mouse Cytomegalovirus Infection in Neonates
05:53

Use of In vivo Imaging to Monitor the Progression of Experimental Mouse Cytomegalovirus Infection in Neonates

Published on: July 6, 2013

14.3K

Cytomegalovirus.

Paul Griffiths1, Sheila Lumley

  • 1Centre for Virology, UCL Medical School, London, UK.

Current Opinion in Infectious Diseases
|October 12, 2014
PubMed
Summary
This summary is machine-generated.

New antiviral drugs show promise for cytomegalovirus (CMV) infections in bone marrow transplant patients. Longer valganciclovir courses improve outcomes for congenital CMV, but hyperimmune immunoglobulin is ineffective in pregnant women.

More Related Videos

qPCR Is a Sensitive and Rapid Method for Detection of Cytomegaloviral DNA in Formalin-fixed, Paraffin-embedded Biopsy Tissue
08:08

qPCR Is a Sensitive and Rapid Method for Detection of Cytomegaloviral DNA in Formalin-fixed, Paraffin-embedded Biopsy Tissue

Published on: July 9, 2014

15.1K
Intracerebroventricular and Intravascular Injection of Viral Particles and Fluorescent Microbeads into the Neonatal Brain
05:51

Intracerebroventricular and Intravascular Injection of Viral Particles and Fluorescent Microbeads into the Neonatal Brain

Published on: July 24, 2016

19.1K

Related Experiment Videos

Last Updated: Apr 22, 2026

Use of In vivo Imaging to Monitor the Progression of Experimental Mouse Cytomegalovirus Infection in Neonates
05:53

Use of In vivo Imaging to Monitor the Progression of Experimental Mouse Cytomegalovirus Infection in Neonates

Published on: July 6, 2013

14.3K
qPCR Is a Sensitive and Rapid Method for Detection of Cytomegaloviral DNA in Formalin-fixed, Paraffin-embedded Biopsy Tissue
08:08

qPCR Is a Sensitive and Rapid Method for Detection of Cytomegaloviral DNA in Formalin-fixed, Paraffin-embedded Biopsy Tissue

Published on: July 9, 2014

15.1K
Intracerebroventricular and Intravascular Injection of Viral Particles and Fluorescent Microbeads into the Neonatal Brain
05:51

Intracerebroventricular and Intravascular Injection of Viral Particles and Fluorescent Microbeads into the Neonatal Brain

Published on: July 24, 2016

19.1K

Area of Science:

  • Virology
  • Infectious Diseases
  • Pharmacology

Background:

  • Cytomegalovirus (CMV) remains a significant pathogen, particularly in immunocompromised individuals like bone marrow transplant recipients.
  • Congenital CMV infection poses risks to neonates, and maternal CMV infection during pregnancy can lead to transmission.
  • Current treatment options for CMV have limitations, necessitating the development of novel therapeutic strategies.

Purpose of the Study:

  • To review emerging treatment options for cytomegalovirus (CMV) infections.
  • To analyze recent clinical trials focusing on bone marrow transplantation, congenital CMV, and pregnancy interventions.
  • To anticipate the clinical integration of novel CMV therapies.

Main Methods:

  • Review of three Phase 2 proof-of-concept studies for novel antiviral drugs in bone marrow transplant patients.
  • Analysis of a randomized controlled trial evaluating extended-duration valganciclovir for symptomatic congenital CMV.
  • Examination of a trial assessing hyperimmune immunoglobulin for primary CMV infection in pregnant women.

Main Results:

  • Three novel antiviral drugs (brincidofovir, maribavir, letermovir) demonstrated activity against CMV in bone marrow transplant patients, targeting different viral mechanisms.
  • A 6-month course of valganciclovir proved superior to a 6-week course for symptomatic congenital CMV in neonates.
  • Hyperimmune immunoglobulin did not significantly reduce placental transmission of CMV in pregnant women with primary infection.

Conclusions:

  • Advances in molecular diagnostics facilitate the evaluation of new CMV treatments.
  • Several novel therapeutic agents show potential for controlling diseases caused by CMV.
  • Optimized treatment durations and new drug classes are crucial for managing CMV infections across diverse clinical scenarios.