Related Experiment Video
Updated: Apr 22, 2026
08:39
Murine Colitis Modeling using Dextran Sulfate Sodium DSS
Published on: January 19, 2010
49.9K
[Colonic morphological changes in experimental chronic colitis induced by dextran sulfate sodium]
Arkhiv Patologii
|October 14, 2014
Summary
This study details the colonic wall changes in experimental chronic colitis induced by dextran sulfate sodium (DSS). The findings provide a model for understanding colitis pathogenesis and evaluating new treatments.
Area of Science:
- Gastroenterology
- Pathology
- Experimental Medicine
Context:
- Chronic colitis is a significant health concern.
- Dextran sulfate sodium (DSS) is a common agent for inducing experimental colitis.
- Understanding the morphological changes is crucial for effective treatment strategies.
Purpose:
- To characterize the detailed morphological alterations in the colonic wall during experimental chronic colitis induced by DSS.
- To establish a reliable animal model for studying colitis.
Summary:
- DSS-induced colitis in mice resulted in epithelial ulcers, mucosal remodeling, and reduced goblet cells and crypt depth.
- Inflammatory infiltration, lymphoid hyperplasia, sclerosis, and neuronal damage were observed in the colonic wall.
- The model mirrors human colitis morphology, aiding in pathogenesis research and preclinical drug evaluation.
Impact:
- Provides a comprehensive morphological description of DSS-induced chronic colitis.
- Validates the use of this model for preclinical drug testing.
- Contributes to a deeper understanding of colitis pathogenesis.
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