Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Drug Toxicity: Allergic Reactions01:30

Drug Toxicity: Allergic Reactions

199
Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial...
199
Hypersensitivity Reactions: Cytolytic Reactions01:01

Hypersensitivity Reactions: Cytolytic Reactions

196
Type II hypersensitivity involves IgG and IgM antibodies targeting cell surface antigens, leading to cell destruction. This can occur through complement activation, antibody-dependent cell-mediated cytotoxicity (ADCC), or acting as opsonins for phagocytosis. When excessive, these reactions cause significant tissue damage.Drug-induced hemolytic anemia is a common example, where drugs like penicillin or cephalosporins bind to red blood cells, forming drug-protein complexes. These complexes...
196
Chemotherapy-Induced Nausea and Vomiting: Neurokinin-1 Receptor Antagonists01:28

Chemotherapy-Induced Nausea and Vomiting: Neurokinin-1 Receptor Antagonists

811
Neurokinin 1 (NK1) receptors are distributed across the GI tract, vagal afferents, and key CNS regions including the central vomiting center and chemoreceptor trigger zone (CTZ) Chemotherapy agents stimulate enterochromaffin cells in the gastrointestinal (GI) tract to release large amounts of substance P (SP). SP is a neuropeptide released by specific sensory nerves in response to many different stressors, including those in the GI mucosa affected by chemotherapy.  SP binds and activates...
811
Desensitization and Tachyphylaxis01:20

Desensitization and Tachyphylaxis

3.3K
Tachyphylaxis is described as a rapid decrease in response to a drug after repeated or continuous administration of the same drug dose. It is a phenomenon where the body becomes less responsive to a particular substance or intervention over time, requiring higher doses or stronger interventions to achieve the same effect. It results from adaptive changes in the body's receptors, signaling pathways, or physiological processes that occur in response to prolonged exposure to a stimulus.
3.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Real-World Diagnostic Patterns and Symptom Progression in Aspirin-Exacerbated Respiratory Disease.

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology·2026
Same author

Implementation of a patient-centered interprofessional education course for undergraduates from five health and medical professions.

Journal of interprofessional care·2026
Same author

Adverse event profile following maintenance olaparib in patients with BRCA-mutated platinum-sensitive relapsed serous ovarian cancer in the phase III SOLO2 trial.

International journal of gynecological cancer : official journal of the International Gynecological Cancer Society·2026
Same author

SALVOVAR: a pragmatic randomized phase III trial comparing the SALVage weekly dose-dense regimen to the standard 3-weekly regimen in patients with poor prognostic OVARian cancers.

Therapeutic advances in medical oncology·2025
Same author

Initial allergenicity assessment of Ulva sp. seaweed flour.

NPJ science of food·2025
Same author

Revisiting the paradigm: Asymptomatic high-grade endometrial cancer diagnosis is not associated with improved outcomes.

European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·2025

Related Experiment Video

Updated: Apr 22, 2026

Evaluating the Effectiveness of Cancer Drug Sensitization In Vitro and In Vivo
09:19

Evaluating the Effectiveness of Cancer Drug Sensitization In Vitro and In Vivo

Published on: February 6, 2015

8.3K

Carboplatin hypersensitivity: evaluation and successful desensitization protocol.

Ilan Bruchim1, Arnon Goldberg, Ami Fishman

  • 1Department of Obstetrics and Gynecology, Meir Medical Center, Kfar Saba, Israel.

Immunotherapy
|October 15, 2014
PubMed
Summary
This summary is machine-generated.

Carboplatin hypersensitivity reactions in gynecologic cancer patients can be managed. Allergy consultation, skin testing, and desensitization offer a convenient and effective strategy for continued carboplatin chemotherapy.

Keywords:
allergic evaluationcarboplatin allergydesensitizationovarian cancerskin test

More Related Videos

Endobronchial Ultrasound-guided Intratumoral Injection of Cisplatin for the Treatment of Isolated Mediastinal Recurrence of Lung Cancer
04:04

Endobronchial Ultrasound-guided Intratumoral Injection of Cisplatin for the Treatment of Isolated Mediastinal Recurrence of Lung Cancer

Published on: February 12, 2017

9.2K
Basophil Activation Test for Allergy Diagnosis
07:22

Basophil Activation Test for Allergy Diagnosis

Published on: May 31, 2021

9.9K

Related Experiment Videos

Last Updated: Apr 22, 2026

Evaluating the Effectiveness of Cancer Drug Sensitization In Vitro and In Vivo
09:19

Evaluating the Effectiveness of Cancer Drug Sensitization In Vitro and In Vivo

Published on: February 6, 2015

8.3K
Endobronchial Ultrasound-guided Intratumoral Injection of Cisplatin for the Treatment of Isolated Mediastinal Recurrence of Lung Cancer
04:04

Endobronchial Ultrasound-guided Intratumoral Injection of Cisplatin for the Treatment of Isolated Mediastinal Recurrence of Lung Cancer

Published on: February 12, 2017

9.2K
Basophil Activation Test for Allergy Diagnosis
07:22

Basophil Activation Test for Allergy Diagnosis

Published on: May 31, 2021

9.9K

Area of Science:

  • Oncology
  • Allergy and Immunology

Background:

  • Immediate hypersensitivity reactions to carboplatin are common in gynecological cancer patients.
  • Previous reactions increase the risk of future hypersensitivity.
  • Management options are crucial for continued treatment.

Purpose of the Study:

  • To evaluate the efficacy of a combined strategy for managing carboplatin hypersensitivity.
  • This strategy includes allergy consultation, skin testing, and desensitization.
  • The aim is to provide a convenient and cost-effective solution for patients.

Main Methods:

  • Patients with documented immediate carboplatin reactions were assessed.
  • Allergy consultation and carboplatin skin testing were performed.
  • A desensitization plan was implemented in a single visit.

Main Results:

  • Out of 49 patients skin tested, 89% showed a positive result.
  • 49 women underwent 207 carboplatin desensitization cycles.
  • 10 patients experienced mild reactions during desensitization; 5 tolerated subsequent carboplatin.

Conclusions:

  • A combined approach of allergy consultation, skin testing, and desensitization is effective.
  • This strategy is cost-effective and patient-convenient.
  • Diagnostic procedures take under 2 hours, and desensitization often avoids hospitalization.