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Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
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Alterations in muscle tone are common manifestations of neurological disorders and reflect dysfunction within different nervous system regions. Spasticity, paratonia, and dystonia represent distinct forms of hypertonia, each with unique mechanisms, clinical features, and diagnostic importance.CharacteristicsSpasticity happens from upper motor neuron lesions and is characterized by velocity-dependent resistance to passive movement. Clinical features include:Exaggerated deep tendon reflexesClonus...
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Related Experiment Video

Updated: Apr 22, 2026

Methods to Quantify Pharmacologically Induced Alterations in Motor Function in Human Incomplete SCI
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Sensory and motor peripheral nerve function and longitudinal changes in quadriceps strength.

Rachel E Ward1, Robert M Boudreau1, Paolo Caserotti2

  • 1Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pennsylvania.

The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
|October 17, 2014
PubMed
Summary

Peripheral nerve function decline in older adults is linked to reduced muscle strength and faster strength loss over time. Maintaining nerve health may be crucial for preserving physical function in aging populations.

Keywords:
AgingMotor neurons.Muscle weaknessPeripheral nerve functionSensory functionStrength

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Area of Science:

  • Gerontology
  • Neurology
  • Kinesiology

Background:

  • Peripheral nerve dysfunction is prevalent in older adults.
  • It is a potential risk factor for age-related strength decline.
  • Longitudinal data on this relationship were previously lacking.

Purpose of the Study:

  • To investigate the longitudinal association between sensorimotor peripheral nerve function and muscle strength.
  • To determine if nerve function predicts future strength and its rate of decline in older adults.

Main Methods:

  • 1,830 older adults from the Health ABC study were assessed over 6 years.
  • Quadriceps strength was measured isokinetically semiannually.
  • Peroneal motor nerve conduction, sensory function (monofilaments, vibration threshold), and neuropathy symptoms were evaluated.

Main Results:

  • Impaired vibration detection and reduced motor nerve amplitude predicted lower strength in men and women.
  • Insensitivity to a 10-g monofilament predicted significantly lower strength and faster decline in women, and lower strength in men.
  • Neuropathy symptoms also predicted strength reduction in women.

Conclusions:

  • Poor peripheral nerve function is a significant predictor of lower muscle strength and accelerated strength decline in older adults.
  • These findings highlight the importance of nerve health for maintaining physical function.
  • Future research should explore interventions to prevent strength loss in individuals with impaired nerve function.