Related Experiment Video
Updated: Apr 22, 2026
Author Spotlight: A Focus on Standardized Salivary Gland Ultrasound Protocol in Connective Tissue Disease Research
Published on: October 13, 2023
Immunoglobulin G subclass analysis in psoriatic arthritis
Amir Haddad1, Arane Thavaneswaran1, Fatima Abji1
1From the Division of Rheumatology, Department of Medicine, University of Toronto Psoriatic Arthritis Program, and the Centre for Prognosis Studies in the Rheumatic Diseases, University Health Network, Toronto Western Hospital, Toronto, Ontario, Canada.A. Haddad, MD, Clinical Research Fellow; A. Thavaneswaran, MMath, Biostatistician; F. Abji, MSc; F. Pellett, BSc; V. Chandran, MBBS, MD, DM, PhD, Assistant Professor of Medicine; J.E. Wither, MD, PhD, FRCPC, Professor of Medicine and Immunology; D.D. Gladman, MD, FRCPC, Professor of Medicine, University of Toronto, Department of Medicine, Division of Rheumatology, and Director, University of Toronto Psoriatic Arthritis Program, and Deputy Director, Centre for Prognosis Studies in the Rheumatic Diseases, University Health Network, Toronto Western Hospital.
Monoclonal gammopathy of undetermined significance (MGUS) is linked to psoriatic arthritis (PsA). While IgG subclass elevations are common in PsA, they don't predict specific disease features but offer insights into MGUS development.
Area of Science:
- Immunology
- Rheumatology
- Clinical Chemistry
Background:
- Monoclonal gammopathy of undetermined significance (MGUS) is prevalent in chronic immune-mediated disorders.
- Elevated immunoglobulin G (IgG) subtypes are frequently observed in psoriatic arthritis (PsA).
Purpose of the Study:
- To investigate IgG subclass profiles in psoriatic arthritis (PsA) patients.
- To correlate IgG subclass levels with specific clinical and serological disease characteristics in PsA.
Main Methods:
- Serum IgG subclass levels were analyzed in 221 PsA patients meeting CASPAR criteria.
- MGUS was identified by specific criteria on serum protein electrophoresis.
- Patients with abnormal IgG subclass levels were compared to those with normal levels.
Main Results:
- Elevations in IgG1-4 were common in PsA, with IgG2 most frequent.
- No clinical-serological correlation was found for abnormal IgG2 levels.
- In MGUS patients, IgG1 elevations were most common and associated with specific biomarkers.
Conclusions:
- IgG subclass determination in PsA did not significantly aid in identifying disease manifestations.
- The study provides insights into the pathological mechanisms underlying MGUS in PsA.
More Related Videos
11:10Antibody Binding Specificity for Kappa (Vκ) Light Chain-containing Human (IgM) Antibodies: Polysialic Acid (PSA) Attached to NCAM as a Case Study
Published on: June 29, 2016
10:31Lymphocyte Isolation from Human Skin for Phenotypic Analysis and Ex Vivo Cell Culture
Published on: April 8, 2016