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Skin blood flow in diabetic patients during cold loading
The Kobe Journal of Medical Sciences
|June 1, 1989
Summary
Cold recovery time (CRT) in finger skin microcirculation increases with age. Diabetics show significantly longer CRTs, indicating this measurement is valuable for assessing circulation in aged individuals and those with diabetes.
Area of Science:
- Vascular Physiology
- Dermatology
- Gerontology
Background:
- Skin microcirculation is crucial for thermoregulation and tissue health.
- Age and diabetes mellitus can impair microcirculatory function.
- Assessing microvascular reactivity is important for identifying at-risk populations.
Purpose of the Study:
- To measure periflux blood flow (PBF) in human fingers.
- To evaluate the response of PBF to cold exposure using cold recovery time (CRT).
- To assess the utility of CRT as an index for skin microcirculation in aging and diabetes.
Main Methods:
- Utilized laser Doppler flowmetry to measure periflux blood flow (PBF) in finger.
- Implemented a cold loading test to assess vascular response.
- Calculated cold recovery time (CRT) as the primary index of microcirculatory function.
Main Results:
- Periflux blood flow (PBF) and cold recovery time (CRT) were measured in participants.
- In healthy individuals, CRT demonstrated a positive correlation with age.
- Diabetic individuals exhibited significantly prolonged CRTs compared to age-matched controls.
Conclusions:
- Cold recovery time (CRT) appears to be a sensitive indicator of age-related changes in skin microcirculation.
- CRT is a valuable tool for evaluating impaired skin microcirculation in individuals with diabetes.
- This method can aid in the assessment of microvascular health in both the aged and diabetic populations.