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Published on: September 23, 2015
Neurotensin-like peptides as potential antipsychotics: modulation of the serotonin system
N V Kost1, V K Meshavkin, E Yu Khashaba
1Research Center of Mental Health, Russian Academy of Medical Sciences, Moscow, Russia, nat-kost@yandex.ru.
Abstract:
Neurotensin-like peptides acting as functional antagonists of serotonin receptors were revealed in the head-shaking test on mice. The neurotensin-like peptides block the serotonin-induced platelet aggregation in humans. Radioligand binding assay showed that neurotensin-like peptides modulate specifi c binding of 5НТ2 serotonin receptor antagonist ketanserin, but have no effect on binding of ligands of 5HT2c receptor mesulergine and 5HT1а receptors NAN-190. Similar effects of neurotensin-like peptides in the experiments in vivo and in vitro suggest that the mechanisms of the detected antipsychotic effect of the peptides can be mediated by serotonin receptors.
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