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Updated: Apr 21, 2026

Investigation of the Transcriptional Role of a RUNX1 Intronic Silencer by CRISPR/Cas9 Ribonucleoprotein in Acute Myeloid Leukemia Cells
Published on: September 1, 2019
Role and regulation of RUNX2 in osteogenesis
M Bruderer1, R G Richards, M Alini
1AO Research Institute Davos, Clavadelerstrasse 8, CH-7270 Davos Platz, Switzerland.martin.stoddart@aofoundation.org.
Abstract:
Runt-related transcription factor 2 (RUNX2) is a transcription factor closely associated with the osteoblast phenotype. While frequently referred to, the complexity of its regulation and its interactions within the osteoblast differentiation pathway are often overlooked. This review aims to summarise the knowledge of its regulation at the transcriptional, translational and post-translational level. In addition, the regulation of RUNX2 by factors commonly used during osteogenic studies will be discussed.
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