[Giant metastatic melanoma arising from an unknown primary site]

Metastatic melanoma arising from an unknown primary site (MUP) accounts for 1-8% of all melanomas. MUP is characterized by a better survival compared to a melanoma with known primary site. We report a case with a 55-year-old male with MUP and a 1.7 kg axillary lymph node metastasis, which was successfully excised. The patient was fully functional and alive 12 months after surgery. The reported favorable post-operative long-term survival of patients with MUP supports that these patients should be treated with an aggressive surgical approach with curative intent.