Related Experiment Video
Updated: Apr 21, 2026

Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils
Published on: January 21, 2020
[A possible correlation between periodontitis and ischaemic heart disease]
Gorm Mørk Hansen1, Palle Holmstrup, Tim Tolker-Nielsen
1Hjertemedicinsk Afdeling, Gentofte Hospital, Niels Andersens Vej 65, 2900 Hellerup. peter.riis.hansen@regionh.dk.
Periodontitis, an inflammatory gum disease, is linked to a higher risk of ischaemic heart disease. This summary reviews current evidence connecting these two prevalent conditions.
Area of Science:
- Oral health
- Cardiovascular health
- Inflammatory diseases
Background:
- Periodontitis is a common chronic inflammatory condition affecting the gums and supporting structures.
- It is triggered by bacterial biofilm accumulation in dental pockets.
- Emerging evidence suggests a connection between periodontitis and systemic health issues, particularly cardiovascular diseases.
Purpose of the Study:
- To summarize the existing scientific evidence linking periodontitis and ischaemic heart disease.
- To provide an overview of the current understanding of this association.
Main Methods:
- Literature review of studies investigating the relationship between periodontitis and ischaemic heart disease.
- Synthesis of evidence from epidemiological and mechanistic studies.
Main Results:
- Multiple studies indicate a correlation between periodontitis and an increased risk of ischaemic heart disease.
- Potential mechanisms include systemic inflammation and shared risk factors.
Conclusions:
- Periodontitis is a significant risk factor for ischaemic heart disease.
- Further research is warranted to elucidate the precise causal pathways and inform clinical practice.
Related Concept Videos
Ischemic Heart Disease: Overview
Atherosclerosis, the primary malefactor, orchestrates this dangerous condition. It manifests as the accumulation of fatty deposits, akin to insidious plaques, within arterial walls. As time elapses, these plaques metamorphose, hardening and...
Coronary Artery Disease II: Pathophysiology
Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies
Coronary Artery Disease III: Clinical Manifestations
Coronary Artery Disease I: Introduction
Psychoneuroimmunology: Cardiovascular Disease
A key area of focus in PNI is the relationship between stress and coronary...
