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Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay
Published on: September 9, 2012
[Hypercoagulability in a patient with meningioma and Factor VLeiden mutation]
Charlotte Gils1, Christina Frøslev-Friis
1Afdeling for Klinisk Biokemi og Farmakologi, Odense Universitetshospital, Sdr. Boulevard 29, 5000 Odense C. charlotte.gils@rsyd.dk.
Abstract:
A 63-year-old woman with meningioma was admitted for surgery. Preoperatively she presented with a clinical state of hypercoagulability in the large central veins visualised by ultrasound. She had no previous history of thrombosis. Surgery was postponed and by biochemical evaluation only Factor VLeiden heterozygosity was found. Weeks later the patient was readmitted for surgery. No bleeding or thrombotic complications were experienced during the operation. The observed condition might be a result of a combination of the Factor VLeiden mutation and her meningioma. Meningioma itself has not been described as a risk factor of venous thrombosis.
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