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Related Experiment Videos

Gene: a gene-centered information resource at NCBI.

Garth R Brown1, Vichet Hem1, Kenneth S Katz1

  • 1National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20892-6510, USA.

Nucleic Acids Research
|October 31, 2014
PubMed
Summary

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The NCBI Gene database integrates comprehensive gene information from diverse sources, using RefSeq genomes as a foundation. This resource provides detailed gene data accessible through various NCBI tools for researchers worldwide.

Area of Science:

  • Bioinformatics
  • Genomics
  • Molecular Biology

Background:

  • The National Center for Biotechnology Information (NCBI) Gene database serves as a central repository for gene-specific information.
  • It integrates data from numerous sources, with NCBI Reference Sequence (RefSeq) genomes forming the core association between sequence and gene identity.

Purpose of the Study:

  • To describe the structure and content of the NCBI Gene database.
  • To highlight the integration of diverse data types and the accessibility of gene information.

Main Methods:

  • Integration of data from RefSeq genomes, transcript, and protein sequences.
  • Incorporation of curated and automated processing from collaborating databases and consortia like Gene Ontology.
  • Assignment of unique, tracked integer identifiers to each gene record.

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Main Results:

  • Gene records contain integrated content including citations, nomenclature, genomic location, gene products, phenotypes, sequences, interactions, variation details, maps, expression data, homologs, protein domains, and external database links.
  • The database provides comprehensive, cross-referenced gene information.

Conclusions:

  • The NCBI Gene database is a vital, integrated resource for accessing and analyzing gene-specific data.
  • Its content is readily available through interactive browsing (Entrez system), programmatic utilities (E-Utilities, Entrez Direct), and bulk transfer (FTP).