Related Experiment Video
Updated: Apr 21, 2026
03:26
Detrusor Underactivity Model in Rats by Conus Medullaris Transection
Published on: August 28, 2020
1.5K
Lower urinary tract function in dementia with Lewy bodies (DLB)
Fuyuki Tateno1, Ryuji Sakakibara, Tsuyoshi Ogata
1Neurology, Internal Medicine, Sakura Medical Center, Toho University, Sakura, Japan.
Summary
Lower urinary tract (LUT) dysfunction is common in Dementia with Lewy bodies (DLB), affecting over 90% of patients. This dysfunction stems from central and peripheral somato-autonomic issues, not just dementia or immobility.
Area of Science:
- Neurology
- Urology
Background:
- Dementia with Lewy bodies (DLB) is a prevalent neurodegenerative disorder.
- Lower urinary tract (LUT) function in DLB remains incompletely understood.
Purpose of the Study:
- To investigate and delineate LUT function in patients diagnosed with DLB.
- To correlate clinical symptoms with urodynamic findings in DLB.
Main Methods:
- Clinical-urodynamic assessment of 32 DLB patients (mean age 75.9 years).
- Electromyography-cystometry performed on all participants.
- Sphincter motor unit potential analysis conducted on 21 patients.
Main Results:
- High prevalence of LUT symptoms, including nocturia (84%) and urinary incontinence (50%).
- Detrusor overactivity identified in 87.1% of patients.
- Minimal postvoid residual volumes observed; neurogenic changes present in 50%.
Conclusions:
- LUT dysfunction is a significant and common clinical feature in DLB.
- Findings suggest somato-autonomic dysfunction (central and peripheral) contributes to LUT issues.
- Results extend beyond dementia severity and immobility as causes of urinary symptoms in DLB.
Related Concept Videos
01:22Dementia l: Introduction
7
Dementia is an acquired, progressive syndrome characterized by a decline in multiple cognitive domains severe enough to impair daily functioning and reduce independence. Although memory loss is a central feature, the diagnosis requires additional deficits involving language, executive function, visuospatial skills, judgment, calculation, or abstract reasoning. These cognitive impairments reflect underlying neurodegenerative or vascular processes that gradually disrupt neuronal networks...
7
01:30Dementia
672
Dementia is a collective term for cognitive disorders primarily affecting memory, thinking, and reasoning. It is not a specific disease but a syndrome, with Alzheimer's disease being the most common cause, accounting for approximately 60-80% of cases. Other types include vascular dementia, Lewy body dementia, and frontotemporal dementia. Dementia affects millions worldwide, particularly older adults, though it is not a normal part of aging.
The progression of dementia is generally gradual....
The progression of dementia is generally gradual....
672
01:24Parkinson Disease ll: Pathophysiology
11
Parkinson disease (PD) is a progressive neurodegenerative disorder primarily affecting movement, with additional non-motor features. Its pathophysiology involves complex interactions among genetic susceptibility, environmental exposures, and cellular dysfunction, including dopaminergic neuron loss, protein aggregation, and mitochondrial impairment.Selective NeurodegenerationA key feature is the degeneration of dopaminergic neurons in the substantia nigra pars compacta, leading to reduced...
11
01:37Neural Regulation
34.5K
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
34.5K
01:23Urinary Bladder
4.6K
The urinary bladder is a hollow, muscular sac that temporarily stores urine before it is expelled from the body. It can hold approximately 600 mL of urine prior to micturition. The bladder is retroperitoneal and located behind the pubic symphysis in the pelvic floor.
In males, the bladder is situated in front of the rectum, while in females, it is positioned anterior to the vagina and uterus. The bladder floor contains an inverted triangular area called the trigone, defined by the two ureteric...
In males, the bladder is situated in front of the rectum, while in females, it is positioned anterior to the vagina and uterus. The bladder floor contains an inverted triangular area called the trigone, defined by the two ureteric...
4.6K
01:28Microbiota of the Urogenital Tract
50
The human urogenital system, once thought to be sterile in healthy individuals, is now recognized as a complex microbial habitat. Advancements in molecular sequencing techniques have revealed that even in healthy adults, the kidneys and bladder harbor microbial populations similar to those found in the distal urethra, albeit in much lower abundance. These resident microorganisms, while generally innocuous, can become opportunistic pathogens under conditions that alter the urogenital...
50