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Updated: Apr 21, 2026

Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly
Published on: February 6, 2020
Enzyme-responsive polymer assemblies constructed through covalent synthesis and supramolecular strategy.
Yan Ding1, Yuetong Kang, Xi Zhang
1Key Lab of Organic Optoelectronics and Molecular Engineering, Department of Chemistry, Tsinghua University, Beijing 100084, P. R. China. xi@mail.tsinghua.edu.cn.
Enzyme-responsive polymer assemblies offer new possibilities for biomaterials and biomedicine. A novel supramolecular strategy enables non-covalent preparation and controlled tuning of these advanced polymer systems.
Area of Science:
- Polymer science and engineering
- Biomaterials science
- Supramolecular chemistry
Background:
- Enzyme-responsive polymer assemblies are crucial for applications in biomaterials, biomedicine, and biosensing.
- Conventional methods involve covalent conjugation of enzyme-responsive moieties to polymer building blocks.
- These assemblies are essential for developing advanced drug delivery systems and diagnostic tools.
Purpose of the Study:
- To explore a supramolecular strategy for preparing enzyme-responsive polymer assemblies.
- To investigate the non-covalent complexation of enzyme-responsive moieties with polymer building blocks.
- To enable controlled tuning of the response rate of these polymer assemblies.
Main Methods:
- Utilizing supramolecular chemistry principles for polymer assembly.
- Non-covalent complexation of enzyme-responsive moieties with polymers.
- Conducting kinetic studies to analyze enzyme-responsive behavior.
Main Results:
- A novel supramolecular strategy was successfully developed for preparing enzyme-responsive polymer assemblies.
- This approach allows for non-covalent complexation, offering advantages over traditional covalent methods.
- Kinetic studies demonstrated the ability to control and tune the response rate of the assemblies.
Conclusions:
- The supramolecular strategy provides a versatile platform for creating advanced enzyme-responsive polymer assemblies.
- This method facilitates the development of tunable biomaterials for diverse biomedical applications.
- Controlled response rates are achievable, enhancing the potential for precise biosensing and drug delivery.
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