Computerised cognitive behaviour therapy for depression in adolescents: study protocol for a feasibility randomised...

Area of Science:

• Adolescent psychiatry
• Digital mental health interventions
• Clinical trial methodology

Background:

• Adolescent depression affects 2% of young people annually.
• Antidepressant medication is not recommended for initial treatment due to side effects and efficacy concerns.
• Cognitive Behavioural Therapy (CBT) is an effective treatment, with computer-administered CBT (CCBT) showing potential for wider reach.

Purpose of the Study:

• To establish the feasibility of conducting a fully powered randomized controlled trial (RCT) for CCBT in adolescents with low mood/depression.
• To assess the clinical and resource implications of implementing CCBT within the National Health Service (NHS).
• To estimate the 'numbers needed' to plan a future RCT evaluating the clinical and cost-effectiveness of CCBT.

Main Methods:

• Adolescents aged 12-18 with depression (MFQ score ≥20) were randomized to CCBT (Stressbusters) or informational websites.
• Primary outcome: Beck Depression Inventory (BDI). Secondary outcomes: generic health (EQ5D-Y, HUI2) and resource use questionnaires.
• Feasibility metrics included acceptability, recruitment/attrition rates, and questionnaire completion rates; monitored via MFQ.

Main Results:

• Data on feasibility metrics such as acceptability, recruitment, attrition, and questionnaire completion rates were collected.
• The study aimed to estimate 'numbers needed' for a future fully powered RCT.
• Beck Depression Inventory (BDI) was the primary outcome measure.

Conclusions:

• This feasibility study provides essential data for planning a larger RCT of CCBT for adolescent depression.
• Findings will inform the clinical and resource implications of implementing CCBT in the NHS for young people.
• The study protocol received ethical approval and was registered (ISRCTN31219579).