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Association between helicobacter pylori infection and primary open angle glaucoma
V Samarai1, N Sharifi, Sh Nateghi
1. abcdefgh1390@yahoo.com.
Global Journal of Health Science
|November 4, 2014
Summary
Helicobacter pylori (H. pylori) infection is significantly more prevalent in patients with primary open-angle glaucoma (POAG) compared to those with cataracts. This suggests a potential link between H. pylori and POAG development.
Area of Science:
- Ophthalmology
- Infectious Diseases
- Gastroenterology
Background:
- Primary open-angle glaucoma (POAG) is a leading cause of irreversible blindness worldwide.
- The etiology of POAG is multifactorial, involving genetic and environmental factors.
- Emerging research suggests potential links between systemic infections and glaucoma pathogenesis.
Purpose of the Study:
- To investigate the seroprevalence of Helicobacter pylori (H. pylori) infection in patients diagnosed with POAG.
- To compare H. pylori infection rates between POAG patients and a control group with cataracts.
- To assess the potential association between H. pylori infection and POAG.
Main Methods:
- A prospective case-control study was conducted.
- Participants included 35 patients with POAG (case group) and 35 age-matched controls with cataracts.
- Serum levels of anti-H. pylori IgG antibodies were measured using ELISA.
Main Results:
- The seroprevalence of H. pylori infection was significantly higher in the POAG group (89.1%) compared to the control group (59.5%) (P=0.008).
- The odds ratio for the association between H. pylori infection and POAG was 5.69 (95% CI: 1.58–20.50).
- These findings indicate a statistically significant association.
Conclusions:
- The study provides evidence suggesting a potential association between Helicobacter pylori infection and primary open-angle glaucoma.
- Further research is warranted to elucidate the mechanisms underlying this association and its clinical implications.
- H. pylori infection may represent a modifiable risk factor or contributing factor in POAG.
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