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Does interferon beta-1a impact pure-tone hearing sensitivity among individuals with multiple sclerosis?
M Samantha Lewis1, Garnett P McMillan, Michele Hutter
1Garnett P. McMillan, PhD, is a Biostatistician at NCRAR, Portland VA Medical Center, Portland, OR. Michele Hutter, MS, was a Research Audiologist at the NCRAR, Portland VA Medical Center, Portland, OR. Robert L. Folmer, PhD, is a Research Investigator at NCRAR, Portland VA Medical Center, and Associate Professor, Department of Otolaryngology/Head and Neck Surgery, Oregon Health & Science University, Portland, OR. Debra Wilmington, PhD, was a Research Investigator at NCRAR, Portland VA Medical Center, Portland, OR and an Assistant Professor, Department of Otolaryngology/Head and Neck Surgery, Oregon Health & Science University, Portland, OR; and is currently an Instructor, Department of Biology, College of Arts and Sciences, Washington State University Vancouver, Vancouver, WA. Linda Casiana, MS, CCRP, was a Research Assistant at NCRAR, Portland VA Medical Center, Portland, OR. Mary Fitzpatrick, NP, was a Nurse Practitioner in the Neurology Service, Portland VA Medical Center; and is currently Medical Science Clinical Liaison, Biogen Idec U.S. Medical, Cambridge, MA. David J. Lilly, PhD, was a Research Investigator/Audiologist at NCRAR, Portland VA Medical Center, Portland, OR and is a Professor Emeritus, Department of Otolaryngology-Head and Neck Surgery, University of Iowa, Iowa City, IA. Dennis Bourdette, MD, is Co-Director, Multiple Sclerosis Center of Excellence West, Portland VA Medical Center, Portland, OR and Chair and Roy and Eulalia Swank Family Research Professor, Department of Neurology, Oregon Health & Science University, Portland, OR. Shannon Overs, MD, is a Staff Physician previously associated with the Neurology Service, Portland VA Medical Center, Portland, OR; Department of Neurology, Oregon Health & Science University, Portland, OR; and Novant Health Neurology Specialists, Charlotte, NC. Michelle Cameron, MD, is Staff Neurologist, Neurology Service, Portland VA Medical Center, and Assistant Professor, Department of Neurology, Oregon Health & Scienc
This study found insufficient evidence that interferon beta-1a causes hearing loss in multiple sclerosis patients, except possibly at 8000 Hz. Further research and hearing monitoring are recommended for patients on this treatment.
Area of Science:
- Neuroscience
- Audiology
- Pharmacology
Background:
- Previous research suggests interferon medications may cause hearing loss.
- The package insert for interferon beta-1a noted decreased hearing sensitivity in some patients.
- This study investigates potential ototoxicity of interferon beta-1a in multiple sclerosis (MS).
Purpose of the Study:
- To determine if MS patients using intramuscular interferon beta-1a have worse hearing thresholds than non-users.
- To assess the ototoxic potential of interferon beta-1a in individuals with MS.
Main Methods:
- Secondary analysis of auditory function data from two larger MS studies.
- Used a linear mixed model to analyze audiometric thresholds.
- Adjusted for confounders including MS subtype, gender, age, disease duration, and disability status.
Main Results:
- Initially, insufficient evidence showed interferon beta-1a was not ototoxic at tested frequencies (except 3000 and 6000 Hz).
- After excluding two subjects, statistical support indicated no ototoxic effect from 250 to 6000 Hz.
- Ototoxic effects at 8000 Hz could not be ruled out.
Conclusions:
- Evidence is insufficient to confirm interferon beta-1a is not ototoxic at all frequencies.
- Further studies are needed to evaluate interferon's effect on auditory function in MS patients.
- Neuroscience nurses should monitor patient hearing during treatment.
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