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Updated: Apr 21, 2026

Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma

Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma

Published on: October 14, 2016

Pediatric osteosarcoma: a single institution's experience.

Vani Vijayakumar¹, Rachel Lowery¹, Xu Zhang¹

¹From the Department of Radiology, the Division of Hematology Oncology, Department of Pediatrics, the Center of Biostatistics and Bioinformatics, the Cancer Institute, the Department of Pathology, the Department of Orthopedic Surgery, and the Department of Radiation Oncology, University of Mississippi Medical Center, Jackson.

Southern Medical Journal

|November 4, 2014

Summary

This summary is machine-generated.

This study evaluated pediatric osteosarcoma survival, finding metastasis at diagnosis significantly impacts outcomes. Survival rates were lower than national data, potentially linked to socioeconomic factors in African American patients.

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Modeling Osteosarcoma Using Li-Fraumeni Syndrome Patient-derived Induced Pluripotent Stem Cells

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Published on: June 13, 2018

Area of Science:

Pediatric Oncology
Cancer Research
Orthopedic Oncology

Background:

Osteosarcoma is a rare bone cancer primarily affecting children and young adults.
Understanding survival predictors is crucial for improving treatment strategies.

Purpose of the Study:

To evaluate survival outcomes in pediatric osteosarcoma patients.
To identify individual predictors influencing survival at a single institution.

Main Methods:

Retrospective review of 28 pediatric osteosarcoma patients diagnosed between 2000-2012.
Analysis of patient demographics, disease characteristics, treatment modalities, and survival data.

Main Results:

Median age at diagnosis was 14 years; most patients were male African Americans with lower limb tumors.
Metastasis at diagnosis was associated with poorer outcomes (P=0.002).
The 5-year overall survival rate was 40%; 13 out of 28 patients died, with a median survival of 2.3 years for deceased patients.

Conclusions:

Survival in this cohort was lower than reported by national databases, possibly due to socioeconomic factors in the African American patient population.
Further research is needed to explore biological and nonbiological factors affecting osteosarcoma prognosis.