A rabbit cisterna magna double-injection subarachnoid hemorrhage model

In recent years, the shift of research interest in the pathological condition after subarachnoid hemorrhage (SAH) from delayed cerebral vasospasm to early brain injury and the development of molecular genetic approaches in animal experiments has resulted in a diversification of animal SAH models. The properties of each animal SAH model thus need to be validated and the purpose of using each animal model should be clarified. This study presents the settings and technical procedures for a rabbit cisterna magna double-injection SAH model and discusses the advantages and limitations of using this model.