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Published on: January 6, 2016
Hybrid ZnO nanorod-polymer brush hierarchically nanostructured substrate for sensitive antibody microarrays
Weihua Hu1, Yingshuai Liu, Tao Chen
1Institute for Clean energy & Advanced Materials, Faculty of Materials and Energy, Southwest University, Chongqing, 400715, China; Chongqing Key Laboratory for Advanced Materials and Technologies of Clean Energies, Chongqing, 400715, China; Chongqing Engineering Research Center for Rapid diagnosis of Fatal Diseases, Chongqing, 400715, China.
Abstract:
A hierarchically nanostructured organic-inorganic hybrid substrate comprising randomly oriented ZnO nanorods on glass slide with coaxially tethered dense polymer brush, POEGMA-co-GMA is reported for highly sensitive antibody microassay, achieving excellent detection specificity, and superior detection limit of as low as 100 fg mL(-1) for biomarkers in human serum within a 1 h assay time.

