Related Experiment Video
Updated: Apr 21, 2026
05:41
Therapeutic Evaluation of Fecal Microbiota Transplantation in an Interleukin 10-Deficient Mouse Model
Published on: April 6, 2022
2.6K
Probiotics prevent Hirschsprung's disease-associated enterocolitis: a prospective multicenter randomized controlled
Xiaolin Wang1, Zhi Li, Zhilin Xu
1Department of Pediatric Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
International Journal of Colorectal Disease
|November 6, 2014
Summary
Oral probiotics significantly reduced the incidence and severity of Hirschsprung's disease-associated enterocolitis (HAEC). This intervention also balanced T lymphocytes and modulated cytokine profiles, decreasing pro-inflammatory markers and increasing anti-inflammatory ones.
Area of Science:
- Gastroenterology
- Pediatric Surgery
- Immunology
Background:
- Enterocolitis (EC) is a severe postoperative complication of Hirschsprung's disease (HD).
- Probiotics may preserve intestinal mucosal integrity.
- The study hypothesized oral probiotics could mitigate Hirschsprung's disease-associated enterocolitis (HAEC).
Purpose of the Study:
- To evaluate the efficacy of oral probiotics in reducing HAEC incidence and severity.
- To assess the impact of probiotics on immune markers in HD patients.
Main Methods:
- A prospective, multicenter, randomized controlled trial was conducted.
- HD patients were randomized into control and probiotic groups.
- Probiotic intervention lasted 4 weeks, with HAEC incidence/severity monitored for 3 months. T lymphocyte subsets and cytokine levels (TNF-α, IFN-γ, IL-6, IL-10) were analyzed.
Main Results:
- The probiotic group showed a significantly lower incidence and severity of HAEC compared to the control group.
- Probiotics led to a balance in T lymphocyte subsets.
- Pro-inflammatory cytokines (TNF-α, IFN-γ, IL-6) decreased, while anti-inflammatory IL-10 increased in the probiotic group.
Conclusions:
- Oral probiotics effectively diminish the incidence and severity of HAEC.
- Probiotics modulate the immune response by balancing T lymphocytes and altering cytokine profiles.
- This suggests a potential therapeutic role for probiotics in managing HAEC.
Related Concept Videos
01:22Probiotics
272
Probiotics are live, non-pathogenic microorganisms that confer health benefits by modulating the gut microbiota. The human gastrointestinal tract harbors a complex microbial ecosystem, and the balance of this microbiota is crucial for digestive and systemic health. Among the most extensively studied and utilized probiotics are species formerly classified within the genera Lactobacillus and Bifidobacterium. These organisms not only naturally colonize the human gut but are also consumed through...
272
01:17Drugs for Treatment of Diarrhea-Predominant IBS
990
Diarrhea-predominant irritable bowel syndrome (IBS-D) is a subtype of IBS characterized primarily by frequent, loose, or watery stools, abdominal pain, and abdominal discomfort. Therapeutic approaches to managing IBS-D include dietary changes, stress management techniques, and pharmaceutical interventions.
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
990
01:20Drugs Affecting GI Tract Motility: Adsorbents as Antidiarrheal Agents
820
Diarrhea is characterized by the occurrence of frequent, watery bowel movements. Various factors can trigger diarrhea, including viral or bacterial infections, foodborne illnesses, side effects from certain medications, and underlying digestive disorders. If not adequately managed, diarrhea can lead to complications such as dehydration, electrolyte imbalances, and nutrient deficiencies. Severe diarrhea can lead to significant weight loss, malnutrition, and weakened immune function.
Adsorbents...
Adsorbents...
820
01:30Development of Human Microbiota
58
The human microbiota begins developing at birth and undergoes continual change as we age. Infancy marks a critical period of microbial sensitivity, offering a “window of opportunity” during which beneficial microbes help mature the immune system. By age three, children typically develop a more stable and diverse microbial community. Newborns acquire microbes from their immediate environment; vaginal delivery favors maternal vaginal microbes, while cesarean births favor microbes from...
58
01:18Drugs Affecting GI Tract Motility: Antimicrobials as Antidiarrheal Agents
583
Acute diarrhea, a common gastrointestinal disturbance, is characterized by the rapid evacuation of fluid stools, leading to an excessive weight in fluid. This condition typically arises from disorders affecting intestinal water and electrolyte transport. It can be triggered by an increased osmotic load within the intestine, excessive secretion of electrolytes and water, mucosal exudation of protein and fluid, or altered intestinal motility. The primary risks of acute diarrhea are dehydration...
583
01:23Renewal of Intestinal Stem Cells
2.6K
The intestinal epithelial lining rapidly renews every 4 to 5 days. The renewal is facilitated by intestinal stem cells (ISCs) located at the base of the crypt– a gland located at the bottom of each villus. ISCs divide asymmetrically to form new stem cells and progenitor daughter cells. The daughter cells are called transit-amplifying (TA) cells which move upwards along the crypt and either differentiate into absorptive cells– the enterocytes or secretory cells– including the...
2.6K