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Related Experiment Video

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Posterior segment involvement in Castleman disease.

Matthew S J Katz1, Sunju Park, David C Gritz

  • 1Departments of *Ophthalmology and Visual Science, and †Epidemiology and Population Health, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, New York.

Retinal Cases & Brief Reports
|November 6, 2014
PubMed
Summary

This case study reports the first patient with Castleman disease (a rare lymphoproliferative disorder) involving the vitreous. Ophthalmic findings in this 28-year-old woman are described.

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Area of Science:

  • Ophthalmology
  • Hematology
  • Oncology

Background:

  • Castleman disease is a rare lymphoproliferative disorder.
  • Vitreous involvement in Castleman disease is not previously documented.

Observation:

  • A 28-year-old woman with known Castleman disease presented with visual complaints.
  • Slit-lamp photography was used to document ophthalmic findings.

Findings:

  • This is the first reported case of Castleman disease with apparent vitreous body involvement.
  • The patient's clinical and ophthalmic findings are described.

Implications:

  • This case expands the understanding of Castleman disease manifestations.
  • Highlights the importance of ophthalmic evaluation in patients with Castleman disease.

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  • Suggests potential for novel therapeutic targets in lymphoproliferative disorders affecting the eye.