Three cases of rhegmatogenous retinal detachment associated with regressed retinoblastoma after conservative tumor therapy
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Updated: Apr 21, 2026

Establishment and Propagation of Human Retinoblastoma Tumors in Immune Deficient Mice
Published on: August 4, 2011
Michiko Tanaka1, Tadashi Yokoi, Makiko Ito
1Departments of *Ophthalmology and Laboratory of Cell Biology, and †Pathology, National Center for Child Health and Development, Tokyo, Japan.
Purpose:
To report three cases of rhegmatogenous retinal detachment associated with regressed retinoblastoma after conservative therapy.
Methods:
Three eyes of three patients with rhegmatogenous retinal detachment, in which retinal breaks were present at the edge of the tumor scar, were treated with vitrectomy and scleral buckling.
Results:
In two eyes, in which cryopexy and silicone oil injection were performed, a preretinal membrane was formed that was comprised primarily of glial cells. Additional vitrectomy and membrane peeling reattached the retina. In one eye, in which photocoagulation and gas injection were performed, an initial vitrectomy and scleral buckling reattached the retina without postoperative membrane formation.
Conclusion:
Vitrectomy and scleral buckling contributed to closure of the irregularly shaped retinal tear at the edge of the tumor scar. Photocoagulation and gas injection instead of cryopexy and silicone oil injection may avoid postoperative glial proliferation from the tumor scar.
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