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Association between the TGFBR2 G-875A polymorphism and cancer risk: evidence from a meta-analysis

Yong-Sheng Huang1, Yu Zhong, Long Yu

  • 1Institute of Basic Medical Sciences and School of Basic Medicine, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China

Asian Pacific Journal of Cancer Prevention : APJCP
|November 7, 2014
PubMed

Insights

The TGFBR2 G-875A polymorphism may decrease cancer risk. This meta-analysis suggests a protective effect of the A allele, but further research is needed for specific cancer subtypes.

Area of Science:

  • Genetics
  • Oncology
  • Molecular Biology

Background:

  • Transforming growth factor-β (TGF-β) signaling disruption is linked to cancer development.
  • The TGF-β receptor II (TGFBR2) mediates crucial growth inhibitory signals.
  • The TGFBR2 G-875A polymorphism has been investigated for its association with cancer risk, but findings are inconsistent.

Purpose of the Study:

  • To conduct a meta-analysis to clarify the association between the TGFBR2 G-875A polymorphism and cancer risk.
  • To provide a more precise estimation of the risk conferred by this genetic variation.

Main Methods:

  • A meta-analysis was performed on data from nine published case-control studies.
  • The analysis included 3,808 cancer cases and 4,489 controls.
  • Statistical analysis examined allele, dominant, and recessive models for the G-875A polymorphism.

Main Results:

  • The G-875A polymorphism showed a trend towards decreased cancer risk for allele A compared to allele G (OR=0.64, 95% CI: 0.55-0.74).
  • A decreased risk was also observed in the dominant model (A/A+G/A vs. G/G, OR=0.76, 95% CI: 0.64-0.90).
  • The recessive model also indicated a reduced risk (A/A vs. G/G+G/A, OR=0.74, 95% CI: 0.59-0.93).

Conclusions:

  • The TGFBR2 G-875A polymorphism appears to be associated with a reduced risk of developing cancer.
  • Larger-scale primary studies are necessary to validate these findings and explore interactions within specific cancer subtypes.

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