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Biomarkers for bladder cancer management: present and future
Fei Ye1, Li Wang2, Mireia Castillo-Martin1
1Department of Pathology, Icahn School of Medicine at Mount Sinai New York City, New York.
American Journal of Clinical and Experimental Urology
|November 7, 2014
Summary
Early detection of bladder cancer is crucial. This review covers established diagnostic tests, new urinary biomarkers, and the genomic landscape for improved bladder cancer diagnosis and surveillance.
Area of Science:
- Oncology
- Biomarker Discovery
- Genomics
Background:
- Accurate bladder cancer detection is vital for early diagnosis, prognosis, treatment response prediction, and recurrence monitoring.
- Urinary bladder cancer diagnostics and surveillance have seen significant improvements.
- While urine cytology is the gold standard, numerous novel urinary biomarkers are emerging.
Purpose of the Study:
- To review established diagnostic tests for bladder cancer.
- To discuss newly identified urinary biomarkers for bladder cancer detection.
- To explore the genomic landscape of bladder cancer for refined understanding and improved strategies.
Main Methods:
- Literature review of established diagnostic tests.
- Identification and summary of novel urinary biomarkers.
- Analysis of recent genomic studies in bladder cancer.
Main Results:
- Urine cytology remains a key diagnostic tool.
- Numerous new urinary biomarkers show promise for sensitive bladder cancer detection.
- Genomic studies are enhancing the understanding of bladder cancer pathogenesis and outcomes.
Conclusions:
- Advances in biomarkers and genomics are transforming bladder cancer diagnosis and surveillance.
- Integrated approaches utilizing cytology, biomarkers, and genomic data offer improved patient management.
- Further research into these areas will lead to more efficient treatment and monitoring strategies.
