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Updated: Apr 21, 2026
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An Efficient Sieving Method to Isolate Intact Glomeruli from Adult Rat Kidney
Published on: November 1, 2018
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Glomerular sparing pattern in primary kidney neoplasms: clinical, morphological and immunohistochemical study
Faisal M Huq Ronny1, Judy Sarungbam1, Xuelin Zhong1
1Department of Pathology, New York Medical College, Westchester Medical Center Valhalla, NY, USA.
American Journal of Clinical and Experimental Urology
|November 7, 2014
Summary
Glomerular sparing, a rare kidney tumor growth pattern, infiltrates renal tubules and glomeruli. This pattern, seen in various cancers, indicates aggressive disease and worse prognosis.
Area of Science:
- Nephrology
- Pathology
- Oncology
Background:
- Glomerular sparing (GS) describes a unique infiltrative pattern in kidney neoplasms where tumor cells replace renal tubules and involve glomeruli.
- This pattern is recognized by pathologists and may indicate an independent risk factor for poor outcomes.
Purpose of the Study:
- To investigate the clinical, pathological, and immunohistochemical characteristics of primary kidney tumors exhibiting the glomerular sparing pattern.
- To determine the incidence and associated features of glomerular sparing in a cohort of kidney neoplasms.
Main Methods:
- Retrospective review of 204 nephrectomy specimens from 2009-2013.
- Clinicopathological data collection and re-evaluation of cases for glomerular sparing pattern.
- Immunohistochemical staining (PAX-8, p63, InI-1) performed on selected cases.
Main Results:
- Seven cases (3.4%) of primary kidney tumors with glomerular sparing pattern were identified.
- Tumor types included clear cell renal cell carcinoma (ccRCC), collecting duct carcinoma, urothelial carcinoma (UC), diffuse large B-cell lymphoma, and malignant rhabdoid tumor.
- Glomerular sparing was more frequent in high-grade UC than RCC and associated with high grade, high stage, large tumor size, and worse prognosis.
Conclusions:
- Primary kidney tumors with glomerular sparing are rare and not specific to any single tumor type.
- Recognition of the glomerular sparing pattern is crucial due to its association with aggressive disease characteristics and poorer prognosis.
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