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Related Concept Videos

Proteomics01:33

Proteomics

10.3K
A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...
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Toxic Reactions: Overview01:26

Toxic Reactions: Overview

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When toxic substances penetrate the human body, they disseminate to various tissues, undergoing metabolic changes. This process yields reactive metabolites that may covalently bind with specific target molecules, resulting in toxicity.
Toxicity falls into two primary categories: local and systemic.
Local toxicity appears at the exposure site, such as protein denaturation caused by caustic substances.
In contrast, systemic toxicity requires the toxic agent's absorption and distribution,...
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Toxicity Testing in Animals01:23

Toxicity Testing in Animals

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Toxicity tests in animals are grounded on two main assumptions: first, the effects observed in laboratory animals can be extrapolated to humans, especially when adjusted for body surface area; second, high-dose exposure in animals is essential to identify potential human hazards from lower doses. This is based on the quantal dose-response concept, which faces the challenge of extrapolating results from relatively few test animals to much larger human populations. For example, a 0.01% incidence...
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Toxicokinetics: Overview01:21

Toxicokinetics: Overview

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Studies that assess how a drug is absorbed, distributed, metabolized, and excreted (ADME) at toxic doses are termed toxicokinetics. Understanding toxicokinetics helps predict adverse drug reactions (ADRs) and manage toxicity in humans.Toxicokinetics differs from pharmacokinetics mainly in the dose levels studied, with toxicokinetics focusing on higher toxic doses. The kinetics at these levels can be non-linear due to altered physiological processes. Toxicodynamics examines the relationship...
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Bioactivation and Tissue Toxicity01:25

Bioactivation and Tissue Toxicity

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Bioactivation is a metabolic process that transforms less reactive substances into highly reactive metabolites, initiating tissue toxicity. This transformation can lead to various toxic effects, including carcinogenesis and teratogenesis. Reactive metabolites are classified into two main types: electrophiles and free radicals.Electrophiles are electron-deficient species and are produced primarily by the enzyme cytochrome P-450 during the metabolism of compounds containing carbon, nitrogen, or...
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Related Experiment Video

Updated: Apr 21, 2026

Deep Proteome Profiling by Isobaric Labeling, Extensive Liquid Chromatography, Mass Spectrometry, and Software-assisted Quantification
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Deep Proteome Profiling by Isobaric Labeling, Extensive Liquid Chromatography, Mass Spectrometry, and Software-assisted Quantification

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Proteomics for systems toxicology.

Bjoern Titz1, Ashraf Elamin1, Florian Martin1

  • 1Philip Morris International R&D, Philip Morris Products S.A., Quai Jeanrenaud 5, 2000 Neuchâtel, Switzerland.

Computational and Structural Biotechnology Journal
|November 8, 2014
PubMed
Summary
This summary is machine-generated.

Proteomics, the study of proteins, offers molecular insights crucial for predictive toxicology. Integrating proteomics into systems toxicology enhances mechanistic understanding and assessment of biological effects.

Keywords:
Computational analysisQuantitative proteomicsSystems toxicology

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Area of Science:

  • Toxicology
  • Systems Biology
  • Proteomics

Background:

  • Current toxicology studies often lack molecular resolution for predictive assessments.
  • A systems toxicology framework integrates system-wide measurements and computational analysis.
  • Proteomic alterations closely reflect biological responses, making them vital for this approach.

Purpose of the Study:

  • To provide an overview of proteomics' technical foundations for systems toxicology.
  • To highlight applications of proteomics in addressing mechanistic toxicology questions.
  • To establish the foundation for integrating proteomics into comprehensive systems toxicology.

Main Methods:

  • Focus on mass spectrometry-based proteomics for quantitative measurements.
  • Summarize experimental methods for quantitative proteomics.
  • Describe computational approaches for deriving biological insights from proteomic data.

Main Results:

  • Proteomics provides molecular resolution for toxicology studies.
  • Case studies illustrate the successful application of proteomics in toxicology.
  • Quantitative proteomics and computational analysis yield mechanistic insights.

Conclusions:

  • Proteomics is essential for a mechanism-based and predictive toxicology.
  • Recent technological advances make proteomics a key component of systems toxicology.
  • Integrating proteomics enhances the comprehensiveness of toxicological assessment frameworks.