Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Protein Families

Protein Families

Protein families are groups of homologous proteins; that is, they have similarities in amino acid sequences and three-dimensional structures. Protein families usually occur because of gene duplication, where an additional copy of a gene is inserted into the genome of an organism. Mutations that change the amino acids but still allow the protein to be properly synthesized, will lead to new protein family members. If these new proteins contain similar amino acids in key...

Protein Families

Protein Families

Membrane Carbohydrates

Membrane Carbohydrates

The plasma membrane is a dynamic barrier composed of lipids, proteins, and carbohydrates. It is the epicenter of many cellular processes required for cell growth and survival. Carbohydrates have unique structural and chemical properties that help the plasma membrane to carry out its functions effectively.
Membrane carbohydrates do not have any hydrophobic region and are exclusively located on the cell's outer surface. The addition of sugar molecules or glycosylation of proteins happens in...

Membrane Carbohydrates

Membrane Carbohydrates

Gene Families

Gene Families

Gene families consist of groups of genes proposed to have originated from a common ancestor. Typically these arise through events in which a gene or genes are mistakenly duplicated during cell division. Unlike their parent genes (which are subject to selection pressure to maintain function), these gene copies do not need to preserve their sequences and may evolve at a relatively faster rate.
Occasionally these regions can be adapted to take on new roles within the organism, becoming novel genes...

Gene Families

Gene Families

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Ti-15Zr-5.5Cu: A dental titanium alloy with robust antibacterial activity and superior corrosion resistance.

iScience·2026

Same author

Successful treatment of a complex Skene's gland cyst: a case report.

Therapeutic advances in urology·2025

Same author

Multi-omics analysis identified LGALS1 (Galectin-1) as a novel therapeutic target for clear cell renal cell carcinoma via targeting epithelial or endothelial cells.

Discover oncology·2025

Same author

The Negative Feedback of the Glutamine/Prostatitis Loop Identified Among 1400 Metabolites and Prostatitis via Mendelian Randomization.

Mediators of inflammation·2025

Same author

Exploring α-synuclein Interaction Partners and their Potential Clinical Implications for Parkinson's Disease.

Neurochemical research·2024

Same author

KDM4B: A promising oncology therapeutic target.

Cancer science·2023

Same journal

Untreated Rosehip Powder/Poly(Lactic Acid)/Poly(3-Hydroxybutyrate-Co-4-Hydroxybutyrate) Electrospun Mats for Wound Dressing Applications.

Biopolymers·2026

Same journal

Synthesis, Characterization, and Antidiabetic Evaluation of Sequence-Modified Liraglutide Analogs in a Drosophila melanogaster Model.

Biopolymers·2026

Same journal

Fabrication of an Antibacterial Alginate/Chitosan Hydrogel Dressing Loaded With CuO Nanoparticles for Wound Dressing Applications.

Biopolymers·2026

Same journal

Effect of Chitosan-Alginate Polyelectrolyte Complex Formation and Multilayer Polymer Configuration on the Characteristics of 3D-Printed Metronidazole-Loaded Periodontal Films.

Biopolymers·2026

Same journal

Phenolic Grafting of Oxidized Cellulose Nanofibers Using Ferulic Acid: Structural and Antioxidant Analysis Toward Bioactive Nanomaterials.

Biopolymers·2026

Same journal

Detection of a Target Nucleic Acid by Ligation-Assisted Fluorescence Enhancement of a Peptide Nucleic Acid (PNA) Twin Probe via Disulfide Binding.

Biopolymers·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Apr 21, 2026

Biochemical and Structural Characterization of the Carbohydrate Transport Substrate-binding-protein SP0092

Biochemical and Structural Characterization of the Carbohydrate Transport Substrate-binding-protein SP0092

Published on: October 2, 2017

Carbohydrate-binding module tribes.

Caio C Carvalho¹, Ngoc N Phan, Yingfei Chen

¹Department of Chemical and Biological Engineering, Iowa State University, Ames, Iowa, 50011.

|November 11, 2014

Summary

This summary is machine-generated.

Researchers explored evolutionary relationships between carbohydrate-binding module (CBM) families. They grouped 27 CBM families into nine tribes based on structural similarities, revealing deeper evolutionary connections.

Keywords:

carbohydrate-binding module protein family protein tribe secondary structure element tertiary structure

More Related Videos

Concanavalin A-Based Sedimentation Assay to Measure Substrate Binding of Glucan Phosphatases

Concanavalin A-Based Sedimentation Assay to Measure Substrate Binding of Glucan Phosphatases

Published on: December 23, 2022

Automated Modular High Throughput Exopolysaccharide Screening Platform Coupled with Highly Sensitive Carbohydrate Fingerprint Analysis

Automated Modular High Throughput Exopolysaccharide Screening Platform Coupled with Highly Sensitive Carbohydrate Fingerprint Analysis

Published on: April 11, 2016

Related Experiment Videos

Last Updated: Apr 21, 2026

Biochemical and Structural Characterization of the Carbohydrate Transport Substrate-binding-protein SP0092

Biochemical and Structural Characterization of the Carbohydrate Transport Substrate-binding-protein SP0092

Published on: October 2, 2017

Concanavalin A-Based Sedimentation Assay to Measure Substrate Binding of Glucan Phosphatases

Concanavalin A-Based Sedimentation Assay to Measure Substrate Binding of Glucan Phosphatases

Published on: December 23, 2022

Automated Modular High Throughput Exopolysaccharide Screening Platform Coupled with Highly Sensitive Carbohydrate Fingerprint Analysis

Automated Modular High Throughput Exopolysaccharide Screening Platform Coupled with Highly Sensitive Carbohydrate Fingerprint Analysis

Published on: April 11, 2016

Area of Science:

Biochemistry
Structural Biology
Evolutionary Biology

Background:

Carbohydrate-binding modules (CBMs) are protein domains involved in carbohydrate recognition.
Currently, 69 CBM families are identified based on sequence divergence, with limited homology between families.
Most CBM families possess beta-sandwich structures, prompting investigation into deeper evolutionary relationships.

Purpose of the Study:

To investigate potential distant evolutionary relationships between different CBM families.
To determine if CBM families, despite sequence divergence, share common ancestry and can be classified into broader 'tribes'.

Main Methods:

Computational superposition of tertiary structures from 53 CBM families with known 3D structures.
Alignment of secondary structure elements and calculation of structural similarity metrics (RMSD, residue similarity).
Inclusion of amino acid chain length and bound ligand data as criteria for tribal assignment.

Main Results:

Successfully superimposed tertiary structures for multiple CBM families.
Assigned 27 CBM families into nine distinct evolutionary tribes.
Identified that eight tribes comprise beta-sandwich structures, while the ninth tribe consists of beta-trefoil structures.

Conclusions:

The study provides evidence for deeper evolutionary connections among CBM families than previously recognized.
Classification into tribes based on structural and functional criteria refines our understanding of CBM evolution.
The findings suggest a common ancestry for many CBM families, particularly those with beta-sandwich folds.