Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Multiple Sclerosis l: Introduction01:19

Multiple Sclerosis l: Introduction

4
Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...
4
Fatigue01:21

Fatigue

1.2K
Fatigue occurs when materials rupture under repeated or fluctuating loads, even at stress levels far below their static breaking strength. It typically results in brittle failure, even for ductile materials. It is a critical consideration in designing machines and structural components subjected to repetitive or varying loads. The nature of these loadings can range from fluctuating loads like unbalanced pump impellers causing vibrations to repeatedly bending a thin steel rod wire back and forth...
1.2K
Self-Regulation01:25

Self-Regulation

346
Self-regulation, also known as self-control, encompasses a range of cognitive and behavioral processes that allow individuals to adjust their internal states and outward actions to align with socially acceptable norms and long-term goals. It plays a fundamental role in adaptive functioning, from resisting impulsive behaviors to persisting through challenging tasks. While its benefits are widely recognized, self-regulation is not limitless. Muraven and Baumeister's theory posits that...
346

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Reward-based prioritization and perceptual feature effects on attentional flexibility in working memory.

Attention, perception & psychophysics·2026
Same author

Cognitive rehabilitation in contemporary neuropsychological practice: an exploratory survey of service delivery, reimbursement, and perceived barriers.

Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists·2026
Same author

Evidence-Based Cognitive Rehabilitation for Persons With Multiple Sclerosis: An Updated Systematic Review 2016 to 2024.

Archives of physical medicine and rehabilitation·2026
Same author

Contributions of default mode network to subjective valuation and maladaptive decision making.

Current opinion in behavioral sciences·2026
Same author

Increased functional network connectivity following cognitive rehabilitation in progressive multiple sclerosis with moderate to severe disabilty: findings from the CogEx study.

Journal of neurology·2026
Same author

Looking Beyond Dose: Identifying Responders and Non-Responders to RehaCom Computerized Cognitive Rehabilitation in Progressive MS-The CogEx Study.

Neurorehabilitation and neural repair·2026

Related Experiment Video

Updated: Apr 21, 2026

Measuring the Motor Aspect of Cancer-Related Fatigue using a Handheld Dynamometer
07:22

Measuring the Motor Aspect of Cancer-Related Fatigue using a Handheld Dynamometer

Published on: February 20, 2020

6.4K

Subjective cognitive fatigue in multiple sclerosis depends on task length.

Joshua Sandry1, Helen M Genova1, Ekaterina Dobryakova1

  • 1Neuropsychology and Neuroscience Research, Kessler Foundation , West Orange, NJ , USA ; Department of Physical Medicine and Rehabilitation, Rutgers - New Jersey Medical School , Newark, NJ , USA.

Frontiers in Neurology
|November 12, 2014
PubMed
Summary
This summary is machine-generated.

Subjective cognitive fatigue in Multiple Sclerosis (MS) increases with time on task and is independent of objective performance. MS patients experience a steeper rise in subjective fatigue compared to healthy controls.

Keywords:
cognitive fatiguefatigabilityprocessing speedtimeworking memory

More Related Videos

The Multiple Sclerosis Performance Test MSPT: An iPad-Based Disability Assessment Tool
11:35

The Multiple Sclerosis Performance Test MSPT: An iPad-Based Disability Assessment Tool

Published on: June 30, 2014

59.0K
Force and Position Control in Humans - The Role of Augmented Feedback
06:31

Force and Position Control in Humans - The Role of Augmented Feedback

Published on: June 19, 2016

8.3K

Related Experiment Videos

Last Updated: Apr 21, 2026

Measuring the Motor Aspect of Cancer-Related Fatigue using a Handheld Dynamometer
07:22

Measuring the Motor Aspect of Cancer-Related Fatigue using a Handheld Dynamometer

Published on: February 20, 2020

6.4K
The Multiple Sclerosis Performance Test MSPT: An iPad-Based Disability Assessment Tool
11:35

The Multiple Sclerosis Performance Test MSPT: An iPad-Based Disability Assessment Tool

Published on: June 30, 2014

59.0K
Force and Position Control in Humans - The Role of Augmented Feedback
06:31

Force and Position Control in Humans - The Role of Augmented Feedback

Published on: June 19, 2016

8.3K

Area of Science:

  • Neuroscience
  • Cognitive Psychology
  • Clinical Neurology

Background:

  • Cognitive fatigue is a common complaint in Multiple Sclerosis (MS).
  • Understanding the relationship between subjective and objective measures of cognitive fatigue is crucial for managing MS symptoms.
  • The impact of cognitive load and time on task on fatigue in MS requires further investigation.

Purpose of the Study:

  • To investigate the interrelationship between subjective and objective cognitive fatigue in MS.
  • To examine the influence of information processing domain (processing speed vs. working memory) and cognitive load on fatigue.
  • To determine the effect of time on task on cognitive fatigue in MS patients and healthy controls.

Main Methods:

  • Thirty-two MS participants and 24 healthy controls performed processing speed and working memory tasks under varying cognitive loads.
  • Subjective cognitive fatigue was assessed using a visual analog scale at multiple time points.
  • Objective cognitive fatigue was measured by task performance.

Main Results:

  • Subjective cognitive fatigue was higher for processing speed tasks, increased over time, and was elevated in the MS group.
  • The MS group exhibited a steeper increase in subjective cognitive fatigue compared to controls.
  • Subjective and objective cognitive fatigue measures were not correlated.

Conclusions:

  • Subjective and objective cognitive fatigue appear to be independent constructs in MS.
  • Cognitive fatigue in MS is primarily influenced by time on task, not cognitive load.
  • Interventions aimed at managing cognitive fatigue in MS should consider the temporal progression of symptoms.