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Updated: Apr 21, 2026

Isolation and Characterization of Microvesicles from Peripheral Blood

Isolation and Characterization of Microvesicles from Peripheral Blood

Published on: January 6, 2017

Extracellular vesicles in hematological disorders.

Anat Aharon¹, Annie Rebibo-Sabbah¹, Inna Tzoran²

¹Microvesicles Research Laboratory, Thrombosis and Hemostasis Unit, Department of Hematology, Rambam Health Care Campus; ; Bruce Rappaport Faculty of Medicine, Technion, Israel Institute of Technology, Haifa, Israel;

Rambam Maimonides Medical Journal

|November 12, 2014

Summary

This summary is machine-generated.

Extracellular vesicles (EVs) play key roles in blood disorders by influencing clot formation and cell signaling. This review examines their contribution to hemoglobinopathies and hematological malignancies.

Keywords:

Extracellular vesicles exosomes hemoglobinopathies leukemia lymphomas microRNA myeloma thrombogenicity

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Characterizing Extracellular Vesicles from Biological Fluids

Characterizing Extracellular Vesicles from Biological Fluids

Published on: February 28, 2025

Area of Science:

Hematology
Cell Biology
Biochemistry

Background:

Extracellular vesicles (EVs) are cell-derived microvesicles involved in intercellular communication.
EVs mediate processes like inflammation, cell signaling, and transfer of biomolecules (proteins, miRNA).
Their roles extend to regulating cell differentiation, proliferation, migration, invasion, and apoptosis.

Purpose of the Study:

To review the significant contribution of extracellular vesicles (EVs) in various hematological disorders.
To highlight the involvement of EVs in conditions such as hemoglobinopathies and hematological malignancies.

Main Methods:

Literature review of studies investigating extracellular vesicles (EVs) in hematological disorders.
Synthesis of current knowledge on EV biogenesis, cargo, and function in blood-related diseases.

Main Results:

EVs are implicated in promoting clot formation and mediating pro-inflammatory responses.
EVs facilitate the transfer of proteins and miRNA, influencing recipient cell behavior.
Specific hematological conditions discussed include sickle cell disease, thalassemia, paroxysmal nocturnal hemoglobinuria, lymphomas, myelomas, and leukemias.

Conclusions:

Extracellular vesicles (EVs) are crucial mediators in the pathogenesis and progression of hematological disorders.
Understanding EV function offers potential therapeutic targets for blood diseases.
Further research into EVs in hematology is warranted to explore diagnostic and therapeutic applications.