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Updated: Apr 21, 2026
Identifying Dysregulated Genes Induced by Kaposi's Sarcoma-associated Herpesvirus KSHV
Published on: September 14, 2010
Diverse clinicopathologic features in human herpesvirus 8-associated lymphomas lead to diagnostic problems
Elizabeth L Courville1, Aliyah R Sohani2, Robert P Hasserjian2
1From the James Homer Wright Pathology Laboratories of the Massachusetts General Hospital, the Department of Pathology, Harvard Medical School, Boston, MA. ecourvil@umn.edu.
Objectives:
Human herpesvirus 8 (HHV8)-associated lymphomas are uncommon, mainly affect men infected with the human immunodeficiency virus (HIV), and usually have a poor prognosis. We sought to characterize the HHV8+ lymphomas seen at our institution since the mid-1990s.
Methods:
We identified 15 patients with HHV8-associated lymphomas and evaluated their clinical and pathologic features.
Results:
Diagnoses included primary effusion lymphoma (PEL) (n = 2), extracavitary PEL (n = 8), intravascular large B-cell lymphoma (n = 1), HHV8+ plasmablastic microlymphoma (n = 3), and germinotropic lymphoproliferative disorder (GLD) (n = 1). The case of GLD progressed to a high-grade HHV8+ Epstein-Barr virus-positive lymphoma, an evolution that has not been previously reported. Four patients were HIV-(three from an HHV8-endemic area). Potentially misleading pathologic features in our series of extracavitary PEL included classic Hodgkin lymphoma-like features, lymph node sinus involvement, and T-cell antigen expression.
Conclusions:
HHV8-associated lymphomas can be clinically and pathologically heterogeneous, with features that may lead to misdiagnosis as other types of lymphoma.
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