Related Experiment Video
Updated: Apr 21, 2026

Optimization of the Retinal Vein Occlusion Mouse Model to Limit Variability
Published on: August 6, 2021
Central retinal vein occlusion in primary antiphospholipid antibody syndrome
Mamta Agarwal1, Jyotirmay Biswas
1From the Medical and Vision Research Foundations, Sankara Nethralaya, Chennai, India.
Purpose:
To report a case of a 20-year-old healthy patient with central retinal vein occlusion in his right eye attributable to primary antiphospholipid antibody syndrome.
Methods:
A 20-year-old man with poor vision in the right eye and diffuse retinal hemorrhages was investigated for infections, autoimmune disease, diabetes, and hypertension. Testing for homocysteine, anticardiolipin antibodies, lupus anticoagulant, and functional assays for protein S and protein C was performed to detect a hypercoagulable state.
Results:
Laboratory investigations revealed elevated levels of IgG and M anticardiolipin antibodies. Long-term oral anticoagulants were given to reduce the risk of future thromboses.
Conclusion:
Antiphospholipid antibodies play an important role in occlusive retinal vascular disorders, especially in young patients without any conventional risk factors.
Related Concept Videos
Venous Thrombosis I: Introduction
Venous Thrombosis III: Interprofessional Care
Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies
Portal Hypertension
Diabetic Retinopathy
Peripheral Artery Disease I: Introduction

