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Metastatic liposarcoma masquerading as an inflammatory granuloma
1From the Vanderbilt Eye Institute, Nashville, Tennessee.
Retinal Cases & Brief Reports
|November 13, 2014
Summary
This case report details an extremely rare instance of retroperitoneal liposarcoma spreading to the eye's choroid. The aggressive tumor required enucleation due to rapid growth and retinal invasion.
Area of Science:
- Ophthalmology
- Oncology
- Pathology
Background:
- Retroperitoneal liposarcoma is a rare malignancy.
- Metastasis of liposarcoma to the eye is exceptionally uncommon.
- Choroidal metastasis can present with varied ocular symptoms.
Purpose of the Study:
- To document a rare case of retroperitoneal liposarcoma metastasizing to the choroid.
- To highlight the clinical and histopathological features of this rare presentation.
- To emphasize the aggressive nature of such metastatic disease.
Main Methods:
- A case report of a 67-year-old woman with decreased vision.
- Ophthalmic examination revealed an extramacular lesion with rapid growth.
- Diagnostic vitrectomy and histopathologic evaluation of the enucleated eye were performed.
Main Results:
- The ocular lesion initially resembled an inflammatory granuloma.
- Diagnostic vitrectomy confirmed malignant cells in the vitreous.
- Histopathology revealed metastatic dedifferentiated liposarcoma to the choroid with retinal penetration and vitreous invasion.
Conclusions:
- Metastatic sarcoma to the choroid is a very rare clinical entity.
- This specific case demonstrated an aggressive tumor with extensive ocular invasion.
- Enucleation was necessary due to the tumor's rapid progression and invasion.
