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Updated: Apr 21, 2026

Isolation and Characterization of Tumor-initiating Cells from Sarcoma Patient-derived Xenografts
Published on: June 13, 2019
Metastatic liposarcoma masquerading as an inflammatory granuloma
1From the Vanderbilt Eye Institute, Nashville, Tennessee.
Purpose:
The purpose of this study was to report a case of retroperitoneal liposarcoma metastatic to the choroid.
Methods:
A case report is presented of a 67-year-old woman who presented with decreased vision from an extramacular lesion resembling an inflammatory granuloma in her left eye. The lesion showed rapid growth and was associated with extensive fibrovascular proliferation.
Results:
Diagnostic vitrectomy showed malignant cells in the vitreous. Histopathologic evaluation of the enucleation specimen showed metastatic, dedifferentiated liposarcoma to the choroid with retinal penetration and vitreous invasion.
Conclusion:
Metastatic sarcoma to the choroid is very rare. In this case, the tumor was quite aggressive and penetrated through the retina, ultimately leading to enucleation.
