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Updated: Apr 21, 2026

Quantification of Vascular Parameters in Whole Mount Retinas of Mice with Non-Proliferative and Proliferative Retinopathies
Published on: March 12, 2022
Functional and morphological evaluation of purtscher retinopathy
Kisaburo Yamada1, Celso S Matsumoto, Kenichi Kimoto
1From the *Department of Ophthalmology, Oita University Faculty of Medicine, Hasama-machi, Yufu-shi, Oita, Japan; and †Centre for Ophthalmology, Institute for Ophthalmic Research, University of Tuebingen, Tuebingen, Germany.
Purtscher retinopathy (PR) causes significant retinal damage, affecting inner and outer retinal layers. Longitudinal analysis reveals dynamic changes in morphology and function, aiding understanding of PR pathophysiology.
Area of Science:
- Ophthalmology
- Retinal Imaging
- Neuroscience
Background:
- Purts cher retinopathy (PR) is a rare condition characterized by visual impairment.
- The precise extent and dynamic nature of retinal damage in PR require further elucidation.
Purpose of the Study:
- To determine the extent of retinal damage in Purtscher retinopathy (PR).
- To evaluate the dynamic changes in retinal morphology and function in a patient with unilateral PR.
Main Methods:
- Longitudinal analysis of retinal morphology using optical coherence tomography (OCT).
- Assessment of retinal function through electroretinography (ERG).
- Study conducted on a single patient with unilateral PR.
Main Results:
- OCT revealed significant inner retinal thickening in the acute phase, progressing to thinning and outer layer alterations in the chronic phase, correlating with cotton-wool patches.
- ERG indicated reduced inner retinal function during the acute phase, with partial recovery observed in the chronic phase.
- These findings highlight the dynamic nature of retinal damage in PR.
Conclusions:
- Both inner and outer retinal layers exhibit morphological and functional alterations in Purtscher retinopathy.
- Dynamic evaluation of retinal morphology and function is crucial for understanding the pathophysiology of PR.

