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Updated: Apr 21, 2026
Isolated Hepatic Perfusion as a Treatment for Liver Metastases of Uveal Melanoma
Published on: January 25, 2015
Hepatocellular carcinoma metastatic to uvea
Robert Wesolowski1, Jeffrey Yau-Huei Chung, Arun Singh
1From the *Department of Solid Tumor Oncology, Taussig Cancer Institute; and †Department of Ophthalmic Oncology, Cole Eye Institute, Cleveland Clinic, Cleveland, Ohio.
Purpose:
To describe a case of uveal metastasis secondary to hepatocellular carcinoma.
Methods:
The authors present a 57-year-old man with known diagnosis of hepatocellular carcinoma, with progressive visual problems in his right eye. Work-up including indirect ophthalmoscopic examination, ocular ultrasonography, and brain magnetic resonance imaging revealed a dome-shaped choroidal mass abutting the optic disk with surrounding shallow exudative retinal detachment.
Results:
A fine-needle biopsy of the lesion confirmed the presence of malignant cells suggestive of metastatic disease from hepatocellular carcinoma. The patient was subsequently treated with brachytherapy. The patient died 3 weeks after the treatment due to pneumonia, which was felt to be unrelated to his ocular disease.
Conclusion:
This is a report of a very unusual case of hepatocellular carcinoma with metastasis to uveal tract.
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