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Updated: Apr 21, 2026

Tumor Treating Field Therapy in Combination with Bevacizumab for the Treatment of Recurrent Glioblastoma
Published on: October 27, 2014
Rebound neovascularization during bevacizumab therapy
Purpose:
To present two cases of rebound neovascularization after bevacizumab treatment.
Methods:
Observational, retrospective case report. A 42-year-old male patient with proliferative diabetic retinopathy and a 68-year-old man with central retinal vein occlusion received treatment with panretinal photocoagulation and intravitreal bevacizumab.
Results:
Both patients showed significant improvement with regression of neovascular vessels after treatment. Nevertheless, on cessation of treatment because of loss to follow-up, both presented with massive neovascularization. This was significantly more severe than the initial presentation.
Conclusion:
After initial suppression of vascular endothelial growth factor by bevacizumab, a rebound phenomenon of neovascularization can occur.
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