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Progressive indocyanine green toxicity
Berna Ozkan1, V Levent Karabaş, Ozgül Altintaş
1From the Ophthalmology Department, School of Medicine, Kocaeli University, Kocaeli, Turkey.
Indocyanine green (ICG) toxicity can cause severe vision loss after epiretinal membrane surgery. Careful use of intravitreal ICG is crucial to prevent retinal damage and preserve sight.
Area of Science:
- Ophthalmology
- Retinal Surgery
Background:
- Epiretinal membranes can impair vision.
- Pars plana vitrectomy is a common surgical approach.
Purpose of the Study:
- To document a case of progressive indocyanine green (ICG) toxicity.
- To highlight potential risks associated with ICG use in retinal surgery.
Main Methods:
- Pars plana vitrectomy for epiretinal membrane removal.
- Intravitreal indocyanine green application focused on the macula.
- Air-fluid exchange and membrane peeling.
Main Results:
- Postoperative vision declined significantly from 0.6 to hand movements.
- Retinal pigment epithelium atrophy, optic atrophy, and retinal holes were observed.
- Arterial sclerosis developed in the affected macula.
Conclusions:
- Intravitreal indocyanine green may exert toxic effects on the retina.
- Avoid unnecessary use of ICG during vitreoretinal surgery.
- Exercise caution when administering intravitreal ICG.
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