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Updated: Apr 21, 2026

Implantation and Evaluation of Melanoma in the Murine Choroid via Optical Coherence Tomography
Published on: December 2, 2022
Bilateral diffuse uveal melanocytic proliferation associated with renal cell carcinoma
1Fundación Oftalmológica Los Andes, Santiago, Chile.
Purpose:
To report a case of bilateral diffuse uveal melanocytic proliferation associated with an asymptomatic renal cell carcinoma.
Design:
Clinical case report.
Methods:
A 70-year-old man presented with a 7-month history of bilateral visual loss. Ophthalmoscopic examination, fluorescein angiography, ocular coherence tomography, and a search for underlying systemic malignancy were performed.
Results:
Examination revealed multiple melanocytic uveal proliferations in both eyes. Fluorescein angiography revealed a pattern of multiple areas of early hyperfluorescence, and ocular coherence tomography showed serous detachment of the central retina. Abdominal computerized tomography scans showed a large tumor in the left kidney and nodular involvement in the right kidney. Pathologic examination revealed a clear cell carcinoma of the kidney.
Conclusion:
A literature review revealed a total of 40 cases of bilateral diffuse uveal melanocytic proliferation. To our knowledge, this is the first case to be associated with renal cell carcinoma.
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