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Updated: Apr 21, 2026
Author Spotlight: Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration
Published on: May 26, 2023
Vitelliform macular detachment associated with Basal laminar drusen is unresponsive to vascular endothelial growth
Deborah Y Chong1, Mark W Johnson
1From the W. K. Kellogg Eye Center, University of Michigan, Ann Arbor, Michigan.
Purpose:
To determine whether vascular endothelial growth factor (VEGF) mediates the leakage in basal laminar drusen (BLD)-associated vitelliform macular detachment (VMD) and whether VEGF blockade can improve visual function in affected eyes.
Methods:
Interventional case report.
Patient:
A 46-year-old woman presented with decreased visual acuity in the right eye and BLD-associated VMD.
Results:
There was no improvement in visual acuity, fundus appearance, or findings of fluorescein angiography and optical coherence tomography after two intravitreal injections of anti-VEGF agents, suggesting that the exudation is not VEGF mediated.
Conclusion:
Ophthalmologists should distinguish BLD-associated VMDs from age-related macular degeneration-associated choroidal neovascularization to avoid exposing patients to the risk of unnecessary intravitreal injections.
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