Related Experiment Video
Updated: Apr 21, 2026
Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation
Published on: May 31, 2016
Angioid streaks and optic nerve head drusen in hyperphosphatemic familial tumoral calcinosis
Dustin Pomerleau1, Richard H Roe, H Richard McDonald
1From The San Francisco Retina Foundation, San Francisco, California, and the Pacific Vision Foundation, California Pacific Medical Center, San Francisco, California.
Purpose:
To describe a patient with angioid streaks and optic nerve head drusen associated with familial tumoral calcinosis (FTC).
Design:
Retrospective, observational case report.
Methods:
The patient's records were reviewed.
Results:
After receiving blunt trauma to the head, the patient presented with loss of vision in the left eye. Fundus examination revealed bilateral angioid streaks, optic nerve head drusen, and choroidal ruptures associated with subretinal hemorrhages. Subsequent physical, laboratory, and radiologic examinations revealed periarticular calcification, elevated serum phosphate levels, and normal calcium levels, consistent with FTC.
Conclusions:
FTC should be considered in the differential diagnosis for patients presenting with angioid streaks and optic nerve head drusen.
Related Concept Videos
01:19Cushing Syndrome II: Pathophysiology
01:27Diabetic Retinopathy