Related Experiment Video
Updated: Apr 21, 2026

Retinal Pigment Epithelium Transplantation in a Non-human Primate Model for Degenerative Retinal Diseases
Published on: June 14, 2021
Focal retinal pigment epithelium breaks in central serous chorioretinopathy
Michael D Ober1, Chiara M Eandi, Lee M Jampol
1From the *Department of Ophthalmology, Henry Ford Health Systems, Detroit, Michigan; †The LuEsther T. Mertz Retina Research Center of Manhattan Eye, Ear, and Throat Hospital, and Vitreous-Retina-Macula Consultants of New York, New York, New York; the ‡Department of Clinic Physiopathology, Eye Clinic, University of Torino, Torino, Italy; and the §Department of Ophthalmology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois.
Purpose:
To describe new evidence supporting a theory on the etiology of the focal retinal pigment epithelium (RPE) leak in central serous chorioretinopathy (CSC).
Methods:
The records of two patients with CSC were reviewed, including examination details and results of fluorescein angiography, fundus autofluorescence imaging, and optical coherence tomography (OCT).
Results:
A defect in the RPE monolayer demonstrated with OCT that corresponded to the site of the focal leak shown by fluorescein angiography was found in both patients.
Conclusion:
The focal leak shown by fluorescein angiography in patients with active CSC is caused by an RPE defect in at least some cases. This finding supports a previously reported theory on the pathogenesis of CSC.
More Related Videos
Related Concept Videos
Diabetic Retinopathy
Anatomy of the Eyeball

