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Updated: Apr 21, 2026

An Alternative and Validated Injection Method for Accessing the Subretinal Space via a Transcleral Posterior Approach
Published on: December 7, 2016
Immediate hyphema after intravitreal injections of ranibizumab
Veronica A Kon Graversen1, Travis Meredith, Maurice B Landers
1Department of Ophthalmology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
Purpose:
To report two cases of immediate hyphema formation after the intravitreal injection of ranibizumab.
Methods:
Retrospective case reports.
Results:
A patient with choroidal neovascularization caused by exudative age-related macular degeneration and a patient with cystoid macular edema caused by branch retinal vein occlusion underwent an intravitreal injection of 0.5 mg/0.05 mL of ranibizumab. The development of hyphema was seen immediately after the intravitreal injection in both cases. One patient was pseudophakic, taking 325 mg of aspirin daily. The other patient was phakic without any anticoagulation history.
Conclusion:
To the best of our knowledge, this is the third report of the development of hyphema associated with intravitreal injections.

