Related Experiment Video
Updated: Apr 21, 2026

A Murine Model of Ischemic Retinal Injury Induced by Transient Bilateral Common Carotid Artery Occlusion
Published on: November 12, 2020
Complete visual recovery after incipient crao due to ocular hypoperfusion in a patient with moyamoya disease
Eleonora M Lad1, Shivanand P Lad, Cindy Ung
1*Department of Ophthalmology, and †Division of Neurosurgery, Duke University Medical Center, Durham, North Carolina; ‡School of Medicine, Stanford University, Stanford, California; §San Diego Retinal Associates, San Diego, California; and Departments of ¶Neurosurgery, and **Palo Alto Medical Foundation, Palo Alto, California.
Purpose:
The purpose of this study was to report a case of an impending central retinal artery occlusion with hypoperfusion in a moyamoya patient.
Methods:
A young, surgically revascularized moyamoya patient experienced severe unilateral vision loss from 20/25 to hand motions because of impending central retinal artery occlusion. The patient was treated with a combination of intermittent ocular massage, intraocular pressure-lowering medications, and aspirin.
Patients:
A case of a moyamoya patient at Stanford University Medical Center.
Results:
Visual acuity was restored to baseline by improving the ocular arterial-venous gradient after prompt administration of ocular massage, intraocular pressure-lowering drops, and aspirin.
Conclusion:
This dramatic result suggests that, if performed in a timely manner, augmentation of ocular perfusion can result in complete restoration of vision in some cases of incipient central retinal artery occlusion.
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