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Detecting Optic Atrophy in Multiple Sclerosis Patients Using New Colorimetric Analysis Software: From Idea to
Maria Pilar Bambo1,2, Elena Garcia-Martin1,2, Susana Perez-Olivan1,2
1a Ophthalmology Department , Miguel Servet University Hospital , Zaragoza , Spain .
Seminars in Ophthalmology
|November 14, 2014
Summary
This study introduces a new software to quantify optic disc pallor in multiple sclerosis (MS) patients. The technology accurately detects hemoglobin changes, aiding in diagnosing optic atrophy and axonal loss in MS.
Area of Science:
- Ophthalmology
- Neuroscience
- Medical Technology
Background:
- Temporal optic disc pallor is a common clinical sign in multiple sclerosis (MS).
- Quantifying optic disc color changes in MS patients has been challenging.
- Optic neuritis is a frequent initial symptom of MS, often leading to optic atrophy.
Purpose of the Study:
- To introduce and evaluate a novel colorimetric software, Laguna ONhE, for quantifying optic disc pallor in MS patients.
- To assess the software's ability to detect optic atrophy and axonal loss.
- To determine the feasibility of integrating this technology into routine clinical practice.
Main Methods:
- Recruited 12 MS patients with a history of optic neuritis.
- Obtained optic disc photographs from all participants.
- Analyzed optic disc color using the Laguna ONhE software, which uses hemoglobin as a reference pigment.
Main Results:
- MS patients exhibited increased optic disc pallor, particularly in the temporal sector.
- Laguna ONhE software detected pallor and indicated lower-than-normal hemoglobin percentages.
- Optic disc hemoglobin measurements showed a good correlation with optic atrophy and axonal loss.
Conclusions:
- The Laguna ONhE software effectively quantifies optic disc pallor in MS patients.
- This technology demonstrates potential for detecting optic atrophy and axonal loss.
- The software is easy to implement in routine clinical settings for MS patient management.
