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Synthesis of 18F-labelled VP 16-213 and podophyllotoxin using acetyl hypofluorite
G W Visser1, A T Bijma, J A Dijksman
1Radio-Nuclide-Centre (RNC), Free University, Amsterdam, The Netherlands.
International Journal of Radiation Applications and Instrumentation. Part A, Applied Radiation and Isotopes
|January 1, 1989
Abstract:
The fluorination of the antitumour agents VP 16-213 and podophyllotoxin using [18F]acetyl hypofluorite is described. Overall labeling yields of 10% and 20% respectively were obtained. The F-atom is found to be introduced into the E-moiety of the compounds, apparently without unwanted conformational changes.