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Multi-state regulation of the dihydrogen phosphate binding affinity to a light- and heat-responsive bis-urea receptor
Sander J Wezenberg1, Matea Vlatković, Jos C M Kistemaker
1Centre for Systems Chemistry, Stratingh Institute for Chemistry, University of Groningen , Nijenborgh 4, 9747 AG, Groningen, The Netherlands.
Abstract:
A responsive bis-urea receptor can be switched between three isomers using light and heat as evidenced by (1)H NMR and UV-vis spectroscopy. Anion binding experiments ((1)H NMR titrations, ESI-MS) reveal a high selectivity for dihydrogen phosphate. Importantly, a large difference in binding affinity to the interchangeable isomers is observed, which is further rationalized by DFT calculations. As a consequence, the amount of bound substrate can be controlled via photo- and thermal isomerization in a three-step process.
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