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[Research progress of targeted therapy in non-small cell lung cancer brain metastases]
1Deportment of Oncology, Shanghai Pulmonary Hospital, Shanghai 200065, China.
Abstract:
Lung cancer is characterized by the highest incidence of solid tumor-related brain metastases, which are reported the incidence ranged 20% to 65%. This is also one of the reasons why it can cause significant mortality. Molecular targeted therapy plays a major role in the management of brain metastases in lung cancer. Targeted agents have become the novel methods for the treatment of lung cancer with brain metastases beyond the whole brain radiation therapy, stereotactic radiosurgery and chemotherapy. Recently, more and more studies and trials laid emphasis on the targeted agents for non-small cell lung cancer (NSCLC) brain metastases treatment. The key point is the efficacy and safety. In this paper, the targeted treatments of NSCLC brain metastases were summarized.
Insights
Brain metastases from lung cancer are common and deadly. Molecular targeted therapy offers a promising new treatment approach for non-small cell lung cancer brain metastases, focusing on efficacy and safety.
Area of Science:
- Oncology
- Neurology
- Pharmacology
Background:
- Lung cancer frequently causes brain metastases, leading to significant mortality.
- Brain metastases from lung cancer have an incidence ranging from 20% to 65%.
Purpose of the Study:
- To summarize targeted treatments for non-small cell lung cancer (NSCLC) brain metastases.
- To review the efficacy and safety of novel targeted agents in managing NSCLC brain metastases.
Main Methods:
- Literature review of studies and clinical trials on targeted agents for NSCLC brain metastases.
- Analysis of existing data on the effectiveness and safety profiles of targeted therapies.
Main Results:
- Molecular targeted therapy is a key treatment modality for lung cancer brain metastases.
- Targeted agents represent novel treatment methods beyond traditional therapies like radiation and chemotherapy.
- Recent research emphasizes targeted agents for NSCLC brain metastases, focusing on efficacy and safety.
Conclusions:
- Targeted therapy is crucial in managing lung cancer with brain metastases.
- Novel targeted agents show promise for treating non-small cell lung cancer brain metastases.
- Further research is needed to fully understand the efficacy and safety of these treatments.
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