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Human chorionic gonadotrophin as an indicator of persistent gestational trophoblastic neoplasia
Soheila Aminimoghaddam1, Fariba Yarandi2, Forough Nejadsalami3
11. Assistant Professor of Obstetrics and Gynecology, Firoozgar Hospital, Iran University of Medical Sciences, Tehran, Iran. dr_aminimoghaddam@yahoo.com.
Background:
Gestational trophoblastic neoplasia (GTN) disease is excessive and inappropriate proliferation of trophoblast after termination of the pregnancy. Many attempts have been made to improve follow-up procedures, but no studies have evaluated Human Chorionic Gonadotrophin (HCG) as a post treatment indicator. Thus we aimed to know β-HCG variability in post treatment pregnancies.
Methods:
40 Molar affected pregnancies were followed post-surgical treatment by serum β-HCG level in a tertiary level hospital. All subjects were treated by evacuation and followed by β-HCG every week for three weeks, then every month for six months.
Results:
30 women were normal (group I) and 10 (group II) diagnosed as GTN cases. Serum β-HCG which obtained serially shown significant differences between two groups (p=0.001). The quantity of β-HCG/week had significantly higher level than normal females (p<0.001) CONCLUSION: Our results suggested that β-HCG serum level could be used as a strong indicator for identifying affected patients at early stage.
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