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Related Concept Videos

Heart Failure III: Clinical Manifestations01:26

Heart Failure III: Clinical Manifestations

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Heart failure (HF) manifests primarily as dyspnea, fatigue, and fluid retention, resulting in peripheral and pulmonary edema. Symptoms may vary depending on which ventricle is more affected, left or right.Left-Sided Heart FailureAlso known as left ventricular failure, this condition results from the left ventricle's inability to fill or eject sufficient blood into the systemic circulation. It leads to pulmonary congestion, which occurs when the left ventricle fails to eject blood effectively...
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Heart Failure I: Introduction01:27

Heart Failure I: Introduction

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Heart failure refers to a clinical syndrome caused by structural or functional cardiac disorders that prevent the heart from pumping an adequate amount of blood to meet the body's metabolic needs. This condition often arises from myocardial infarction or ischemia, leading to decreased cardiac output, reduced tissue perfusion, impaired gas exchange, fluid volume imbalance, and decreased functional ability.Heart failure can result from disruptions in the mechanisms that regulate cardiac output...
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Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

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Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
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Pathophysiology of Heart Failure01:17

Pathophysiology of Heart Failure

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Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
4.8K
Heart Failure VII: Nursing Interventions01:30

Heart Failure VII: Nursing Interventions

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The first step in nursing management of a patient with heart failure involves thoroughly assessing the patient's medical history.Subjective Data: Obtain the patient's medical history of coronary artery disease, hypertension, myocardial infarction, and symptoms like dyspnea, orthopnea, and paroxysmal nocturnal dyspnea.Objective Data: Conduct a physical examination to identify findings such as jugular vein distention, pulmonary crackles, tachycardia, murmurs, peripheral edema, and vital signs,...
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Imbalances in Cardiac Output01:26

Imbalances in Cardiac Output

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The heart's primary function is to pump blood throughout the body, maintaining a balance between blood sent out (cardiac output) and blood returning (venous return). If this balance is disrupted, it can result in congestive heart failure (CHF), a severe condition where the heart becomes an inefficient pump, leading to inadequate blood circulation.
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send...
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An Experimental Model of Myocardial Infarction for Studying Cardiac Repair and Remodeling in Knockout Mice
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Heart failure and galectin 3.

Gabriela Suarez1, Gary Meyerrose1

  • 11 Department of Internal Medicine, 2 Department of Cardiology, Texas Tech University Health Sciences Center, Lubbock, TX, USA.

Annals of Translational Medicine
|November 19, 2014
PubMed
Summary
This summary is machine-generated.

Galectin-3 shows prognostic value in predicting mortality for patients with chronic heart failure (CHF). This biomarker is linked to cardiac aging and fibrotic remodeling, impacting diastolic function.

Keywords:
Galectin 3diastolic HFsystolic heart failure (HF)

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Area of Science:

  • Cardiology
  • Biomarkers
  • Aging

Background:

  • Medical innovations increase patient longevity, leading to a higher prevalence of heart failure (HF).
  • HF presents significant healthcare costs, with over a million US hospital admissions annually.
  • Cardiac aging involves structural and functional changes, including fibrosis and diastolic dysfunction.

Purpose of the Study:

  • To review the prognostic value of galectin-3 in patients with moderate to advanced chronic heart failure (CHF).
  • To assess galectin-3 as an independent predictor of mortality in CHF patients.

Main Methods:

  • Review of existing literature on galectin-3 and its role in heart failure.
  • Analysis of galectin-3 as a biomarker in moderate to advanced chronic heart failure.

Main Results:

  • Galectin-3, secreted by macrophages, promotes cardiac fibroblast proliferation and collagen deposition.
  • Galectin-3 is associated with fibrotic remodeling, leading to ventricular dysfunction and diastolic stiffness.
  • Galectin-3 is an independent predictor of mortality in patients with moderate to advanced CHF.

Conclusions:

  • Galectin-3 is a significant prognostic biomarker in chronic heart failure.
  • Understanding galectin-3's role can aid in risk stratification and management of CHF patients.